A review of 200 new global studies published in the week of Sept 7th, 2026 yields zero (0) Additive findings. However, one study is highly supportive of BRIGHT core thesis held consistently across our 24 years of operation.
Executive Summary: Horizon Filter Evaluation – Week 37, Sept 7th, 2026
This week, the Horizon Filter evaluated 200 global studies across the traumatic brain injury (TBI) and cerebral palsy (CP) pipeline. If you look only at the surface of modern research, it looks remarkably impressive. The database is flooded with high-tech, shiny engineering tools: multi-omic AI arrays, functional gut metagenomics, and advanced neuromodulation protocols like bilateral tDCS.
But when you filter these studies close, one by one, a devastating structural flaw emerges. Mainstream research is treating these brilliant tools exactly like getting a shiny new hammer for Christmas and trying to use it to bake cookies.
They are taking sophisticated neuromodulation tools—as seen in the recent HAND-IN tDCS trial (PMID: 42693609)—and plugging them into the exact same dead-end, linear, single-target clinical trial designs that have yielded a near-100% failure rate for thirty years. They think the tool fixes the system. They don’t realize that if the foundational recipe is broken, the tool doesn’t matter.
Out of 200 studies, only one single paper holds true structural value this week: PMID: 42695077, written by neurosurgeon José Luís Alves, titled: “The unsolvable problem of traumatic brain injury (or how to stop wasting money in fruitless research)”.
The White Flag From Inside the Castle
Dr. Alves’s work is not a standard, safe academic paper written to secure a routine grant. It is a systemic assault on the foundational reasoning of his own peers.
- It attacks a multi-billion-dollar global industry: For the last 30 years, the global approach to Traumatic Brain Injury (TBI) has been highly linear. Scientists take an animal model, inflict a specific type of head trauma, apply a single drug molecule, and look for a single outcome. Billions of dollars from institutions like the NIH and major pharma have been poured into this exact pipeline.
- The failure rate is effectively 100%: Nearly every major Phase III clinical trial for TBI neuroprotective drugs over the last few decades has failed.
- His Thesis: Alves argues that TBI is not a single, linear medical condition that can be fixed with a single “magic bullet” drug. It is a highly complex, chaotic, non-linear systems failure. By calling the current path “fruitless,” he is telling the scientific establishment that their foundational methodology is broken.
A 24-Year Echo of the BRIGHT Blueprint
While it is validating to see an elite, deeply credentialed institutional neurosurgeon finally publish this critique, the logic here is not new.
Decades before the institutional medical world hit this wall, the foundational logic for this exact systems framework was already written down. Operating under extreme duress, BRIGHT solved this exact puzzle. In the January 2002 BRIGHT Brain Injury Manifesto, the exact reality was laid out:
“Treatment must be based on understanding how that injury results in an ‘undesired’ movement pattern becoming the stable attractor. Opportunities must be presented and facilitated to allow new more desirable patterns to de-stabilize the undesirable pattern and become the stable pattern.” (CPCure Manifesto, January 2002)
In 2002, BRIGHT called out mainstream medicine for its static, linear dead-ends. BRIGHT knew then that you couldn’t just apply isolated therapies or inject stem cells without measuring and targeting the non-linear variables of the entire dynamic system.
The Bottom Line
This paper represents a profound milestone for our community. It provides independent, authoritative validation from someone inside the system who sees the truth. It proves that even if you spend decades following the system’s exact rules—accumulating an MD, a PhD, fellowships, and eventually an MBA in Project Management to navigate hospital bureaucracy—you still inevitably arrive at the exact same brick wall. You still realize that the establishment is running in circles.
The establishment is finally catching up to the systems logic BRIGHT established 24 years ago. They are finally realizing that a shiny new hammer won’t bake the cookies. The systems framework was right from Day Zero.
| Status | Core Finding & Target Domain | Source / PMID | |
| 1 | 🟡 Supportive (Acute / Clinic Bound) | Neonatal reflex mapping for early brain injury ➔ DECODE Target: Evaluates five neonatal reflexes (optomotor, PLR, VOR, etc.) as rapid biomarkers. Limited to the early 0–6 month acute neurodevelopmental window and clinic testing conditions. | 42701326 |
| 2 | 🟡 Supportive (Clinic Bound) | Structural covariance networks in adolescent mTBI ➔ DECODE Target: Identifies reduced cortical thickness/surface area in the executive control network. Disqualified from home use due to reliance on clinical structural MRI quality-control metrics. | 42701047 |
| 3 | 🔴 Legacy (Animal) | Scalp acupuncture and necroptosis pathway in rats ➔ CLEAR Limits: Evaluates modulation of RIP1/RIP3/MLKL-mediated necroptosis and secondary neuroinflammation post-ICH. Disqualified as a preclinical male rat model. | 42700937 |
| 4 | 🔴 Legacy (Out of Scope) | Under-reporting of hypoxic-ischaemic injury ➔ DECODE Limits: Evaluates clinical diagnostic gaps on routine head CT and MRI scans during post-cardiac arrest neuroprognostication. | 42700919 |
| 5 | 🟡 Supportive (Clinic Bound) | EEG spectral analysis of multisensory rooms ➔ TUNE Target: Objective tracking of resting-state EEG alpha power/ratios before and after sensory stimulation. Dependent on complex, high-density clinical EEG arrays. | 42700891 |
| 6 | 🔴 Legacy (Animal) | Brexpiprazole for cognitive recovery in rats ➔ UPDATE Limits: Examines dose-specific reductions in cortical lesion volume and spatial learning changes after controlled cortical impact. Limited to a preclinical rat study. | 42700881 |
| 7 | 🔴 Legacy (Out of Scope) | Review of the Nrf2/HO-1 redox paradox ➔ CLEAR Limits: Contextual framework evaluating cytoprotection vs. iron-mediated ferroptosis across cell types. Retrospective review lacking direct architecture expansion. | 42700879 |
| 8 | 🔴 Legacy (Clinic Bound) | Cervical spine injury patterns in child abuse ➔ GUIDE Limits: Multivariable regression linking low GCS and intubation to ligamentous injuries on screening CT/MRI. Out-of-scope acute trauma triage logic. | 42700814 |
| 9 | 🟡 Supportive (Clinic Bound) | AI multi-omics prioritization of Hydroxytyrosol ➔ PRIME Target: Computationally maps the TXNIP-NLRP3 inflammasome axis in TBI using transcriptomic arrays. Disqualified from deployment due to relying on public GEO datasets and purely in silico predictions. | 42700807 |
| 10 | 🔴 Legacy (Animal) | Mitochondrial proteomics of PCABI in Wistar rats ➔ FUEL Limits: Evaluates complex I activity and calcium retention recovery via the SIRT1 activator SRT1720. Limited to an invasive animal framework. | 42700645 |
| 11 | 🔴 Legacy (Out of Scope) | Confounding by indication in pediatric cEEG ➔ DECODE Limits: Explores statistical yield issues of continuous EEG tracking within severe pediatric trauma intensive care settings. | 42700638 |
| 12 | 🟡 Supportive (Clinic Bound) | Action observation vs. virtual reality in UCP ➔ GUIDE Target: Compares AOT telerehabilitation and XBOX Kinect systems on upper extremity structure functions. Requires standard clinical outcome scores (MAS, SCUES, JTHFT). | 42700622 |
| 13 | 🔴 Legacy (Animal) | Photobiomodulation and hydrogen co-therapy in mice ➔ UPDATE Limits: Measures locomotor protection and reduced glial activation at 24 hours post-hypoxic-ischemic injury. Confined to an acute mouse model. | 42700227 |
| 14 | 🔴 Legacy (Out of Scope) | Surgical management of syndromic C2-C3 anterolisthesis ➔ CEMENT Limits: Case report detailing surgical decompression and posterior fusion in a toddler with Charcot-Marie-Tooth disease mislabeled as CP. | 42699920 |
| 15 | 🔴 Legacy (Out of Scope) | Retrospective genetic phenotyping in TBL1XR1 variant ➔ DECODE Limits: Clinical case profile identifying generalized dystonia via whole-exome sequencing in an adult adult historically misdiagnosed with CP. | 42699641 |
| 16 | 🔴 Legacy (Animal) | Glia-mediated lactate shuttle in radiation injury ➔ CLEAR Limits: Tracks microglial phenotypic transitions (M1/M2) during myelin phagocytosis using mouse snRNA-seq and glia co-cultures. Preclinical mechanistic study. | 42699581 |
| 17 | 🔴 Legacy (Clinic Bound) | Ultrasonography of optic nerve sheath diameter ➔ DECODE Limits: Assesses bedside ONSD as an emergency prognosis marker for 3-day mortality in acute TBI. Confined to hospital emergency medicine settings. | 42699344 |
| 18 | 🔴 Legacy (Animal) | Neuroblast interactions and OPC cortical migration ➔ CLEAR Limits: Live three-dimensional imaging of transient adherens junctions in neonatal mouse cortical lesion models. Preclinical cellular mapping. | 42698966 |
| 19 | 🔴 Legacy (Out of Scope) | Review of neuroendocrine immune regulation by AVP ➔ PRIME Limits: Conceptual review tracing how arginine vasopressin alters systemic HPA axis feedback and blood-brain barrier disruption. | 42698947 |
| 20 | 🟡 Supportive (Clinic Bound) | Chinese woodblock printing conceptual framework for PD ➔ SYNC Target: Sensorimotor rehabilitation hypothesis linking fine-motor carving to experience-dependent neuroplasticity. Lacks direct empirical data or operational hardware execution. | 42698827 |
| 21 | 🔴 Legacy (Out of Scope) | Downbeat nystagmus in status epilepticus ➔ DECODE Limits: Clinical case track linking myoclonic status epilepticus to anoxic brain damage on continuous EEG monitoring. | 42698797 |
| 22 | 🟡 Supportive (Clinic Bound) | Multi-omics mapping of TIM-4 in neuroinflammation ➔ DECODE Target: Uses WGCNA, phosphoproteomics, and ATAC-seq to prioritize microglial regulatory hubs. Translation hampered by combined mouse and patient-derived tissue profiling datasets. | 42698755 |
| 23 | 🟡 Supportive (Clinic Bound) | Crossover study of low-intensity transcranial ultrasound ➔ TUNE Target: Characterizes immediate excitatory threshold dynamics in human M1 via MEP amplitudes. Tied to highly technical crossover lab protocols and single-pulse TMS equipment. | 42698681 |
| 24 | 🔴 Legacy (Out of Scope) | Retrospective review of DCD organ donation potential ➔ GUIDE Limits: Administrative audit analyzing potential donation rates after circulatory death within German university hospitals. | 42698497 |
| 25 | 🟡 Supportive (Clinic Bound) | Alerting network ERP characteristics in athletes ➔ TUNE Target: Maps N1 and P2 peak variations during dual-cue tasks to track athletic cognitive plastic modifications. Requires formal laboratory EEG setup. | 42698480 |
| 26 | 🔴 Legacy (Out of Scope) | Systematic review of P7C3 targeted therapeutics ➔ FUEL Limits: Synthesizes discovery paths, NAMPT enzyme tracking, and preclinical structure-activity metrics without introducing new operational modules. | 42698301 |
| 27 | 🔴 Legacy (Out of Scope) | Scoping review of autism assessment in motor conditions ➔ GUIDE Limits: Qualitative scoping review mapping diagnostic tool overlap between early-onset motor disorders and ASD. | 42698126 |
| 28 | 🟡 Supportive (Clinic Bound) | Restorative normalization vs. compensatory amplification ➔ TUNE Target: Theoretical cognitive framework formalizing design rules for stratified neuromodulation. Lacks hardware-level integration blueprints or software logic code. | 42697957 |
| 29 | 🔴 Legacy (Animal) | YTHDF1-CAP1 axis in actin turnover and depression ➔ CLEAR Limits: Tracks hyperalgesia and impaired synaptic transmission in the ACC of Ythdf1 knockout mice. Preclinical behavior study. | 42697900 |
| 30 | 🔴 Legacy (Out of Scope) | Retrospective analysis of preterm morbidity patterns ➔ DECODE Limits: Longitudinal tracking of neurodevelopmental impairment (NDI) rates across two decades using the ANZ Neonatal Network register. | 42697710 |
| 31 | 🔴 Legacy (Out of Scope) | Narrative review of bilingual education neuroscience ➔ TUNE Limits: Review of frontoparietal white matter structural variations across developmental eras. Lacks objective neuro-repair loop architecture. | 42697629 |
| 32 | 🟡 Supportive (Clinic Bound) | Dried plasma biosampling lateral flow device for TBI ➔ DECODE Target: Analytical validation of capillary blood biosampler paired with Quanterix Neurology 4-Plex assays. Disqualified from autonomous home use due to complex chemical rehydration steps. | 42697480 |
| 33 | 🔴 Legacy (Animal) | Astrocytic PHGDH-derived serine in poststroke remodeling ➔ UPDATE Limits: Details endothelial SLC38A2 transporter signaling and mTORC1 dynamics in astrocyte-specific knockout mice. Restricted to an animal tissue model. | 42697478 |
| 34 | 🟡 Supportive (Clinic Bound) | Functional connectome gradient mapping of PSU ➔ DECODE Target: Combines representational similarity profiles with transcriptomic datasets to map principal gradients in the frontal pole. Tied to high-cost neuroimaging connectomics. | 42697356 |
| 35 | 🔴 Legacy (Animal) | miR-642b-3p targeting SERPINE1 in rat stroke models ➔ CLEAR Limits: Investigates microglial M2 polarization and NLRP3 suppression via intracerebroventricular agomir injections in collagenase-induced rat ICH models. | 42697258 |
| 36 | 🔴 Legacy (Out of Scope) | Registry erratum regarding selective dorsal rhizotomy ➔ GUIDE Limits: Minor data update or erratum regarding surgical variations within the Cerebral Palsy Research Network registry. | 42696785 |
| 37 | 🔴 Legacy (Animal) | SPARC-targeted ZnS/BSA nanoparticles in rat SAH ➔ CLEAR Limits: Multi-mechanistic mitigation of early brain injury via responsive H2S/Zn2+ chemical release profiles. Restricted to preclinical rodent interventions. | 42696702 |
| 38 | 🟡 Supportive (Clinic Bound) | Meta-analysis of rTMS and iTBS in Multiple Sclerosis ➔ TUNE Target: Synthesizes Randomized Controlled Trials evaluating cortical excitability and white matter microstructural adjustments. Lacks novel standardized programming templates. | 42696515 |
| 39 | 🔴 Legacy (Animal) | NPB-1575 regulation of microglial polarization ➔ CLEAR Limits: Preclinical abstract exploring ischemic brain injury recovery tracking via IRS2 intracellular signaling pathways. | 42696501 |
| 40 | 🔴 Legacy (Out of Scope) | Structured narrative review of resveratrol mechanisms ➔ FUEL Limits: Evaluates multi-pathway preclinical data (SIRT1/AMPK) while stating human psychiatric trials fail to establish efficacy. | 42696458 |
| 41 | 🔴 Legacy (Animal) | Erratum on arbutin neuroprotection in zebrafish ➔ CLEAR Limits: Preclinical tracking correction regarding Nrf2/NF-κB inflammatory signaling pathways in a traumatic brain injury zebrafish model. | 42696210 |
| 42 | 🔴 Legacy (Animal) | Microglial morphometrics under diverse stress profiles ➔ CLEAR Limits: Explores subregion-dependent soma-remodeling in the central amygdala and habenula across mouse restraint models. Confined to preclinical anatomy. | 42696151 |
| 43 | 🔴 Legacy (Out of Scope) | Narrative synthesis of signaling along the skin-brain axis ➔ PRIME Limits: Compiles sensory neuron-immune cell interaction reviews and AI-enabled digital phenotyping concepts without primary data. | 42696144 |
| 44 | 🔴 Legacy (Out of Scope) | Quality and reliability assessment of ChatGPT responses ➔ GUIDE Limits: Evaluates the DISCERN, PEMAT-P, and readability scores of LLM answers regarding cerebral palsy for patient families. | 42696131 |
| 45 | 🔴 Legacy (Out of Scope) | Neurodevelopmental review of reward dysregulation in ADHD ➔ DECODE Limits: Precision psychiatry review tracking computational reinforcement learning models and dopaminergic variations across development. | 42696117 |
| 46 | 🔴 Legacy (Out of Scope) | Meta-analysis of European PROM usage post-injury ➔ GUIDE Limits: Systematic review evaluating persistent 1-year EuroQol-5D index deficits and outcome reporting heterogeneity in severely injured patient cohorts. | 42695938 |
| 47 | 🟡 Supportive (Clinic Bound) | Validation of the Multiparty Communication Questionnaire ➔ GUIDE Target: Psychometric tracking of cognitive-communication deficits in group settings using classical test theory. Relies on subjective self-report profiles rather than closed-loop stream telemetry. | 42695900 |
| 48 | 🟡 Supportive (Clinic Bound) | Mass spectrometry-based glycoproteomics strategy ➔ CLEAR Target: Quantifies IgG Fc core fucosylation alterations post-injury directly from crude serum protein. Restricted by high-cost, specialized clinical chromatography systems. | 42695559 |
| 49 | 🟡 Supportive (Clinic Bound) | Service evaluation of the ACE-III cognitive screen ➔ DECODE Target: Examines domain correlations between the Addenbrooke’s Screen and formal WAIS-IV profiles in chronic ABI. Dependent on manual neuropsychological testing protocols. | 42695554 |
| 50 | 🟡 Supportive (Clinic Bound) | Prefrontal functional near-infrared spectroscopy in pregnancy ➔ DECODE Target: Tracks resting-state PFC neuroconnectivity shifts via fNIRS to trace maternal internalizing symptom profiles. Dependent on laboratory neuroimaging systems. | 42695508 |
| 51 | 🔴 Legacy (Out of Scope) | Preclinical environmental enrichment modeling ➔ TUNE Limits: Abstract-level citation missing explicit descriptive text; focused on generic preclinical frameworks linking HPA axis variations to neuroplasticity. | 42695508 |
| 52 | 🟡 Supportive (Clinic Bound) | Synergistic metal ion network pharmacology of Longgu ➔ PRIME Target: Tracks Ca, Mg, and Zn ionostatic regulation of neuronal excitability and gut-brain axes in traditional medicine. Limited to descriptive review frameworks without custom software integration. | 42695497 |
| 53 | 🔴 Legacy (Out of Scope) | Narrative review of epigenetic dysregulation in preterm brains ➔ DECODE Limits: Traces pathobiological cascades involving DNA methylation and microRNA variations. Lacks automated real-time software execution logic. | 42695417 |
| 54 | 🟡 Supportive (Clinic Bound) | Multi-target cytoprotective evaluation of L-Carnosine ➔ FUEL Target: Maps natural antioxidant binding patterns against methylglyoxal and AGE cellular toxicity pathways. Restricted by preclinical dependency and clinical trial bio-availability tracking gaps. | 42695325 |
| 55 | 🟡 Supportive (Clinic Bound) | Review of ketone body metabolic neuroprotection ➔ FUEL Target: Summarizes β-hydroxybutyrate pathways for preserving cerebral energy supplies during stroke cascades. Lacks primary experimental verification or hardware architecture. | 42695252 |
| 56 | 🔴 Legacy (Out of Scope) | Case report of complete thoracoabdominal avulsion ➔ GUIDE Limits: Clinical trauma tracking detailing surgical plication and subsequent progression to acute brain death. Out of scope for home-based chronic care systems. | 42695110 |
| 57 | 🟡 Supportive (Clinic Bound) | Application of modern systems theory to TBI protocols ➔ TUNE Target: Conceptual outline reframing the brain as a complex integrated organ to design multi-tier research trials. Contains no hardware or software blueprints. | 42695077 |
| 58 | 🔴 Legacy (Clinic Bound) | Trauma mapping of penetrating skull base stab injuries ➔ GUIDE Limits: Emergency frontotemporal craniotomy and external ventricular drain tracking protocols. Strictly bound to acute intensive care neurosurgery settings. | 42695051 |
| 59 | 🟡 Supportive (Clinic Bound) | Cross-phenotypic genomic associations in stroke recovery ➔ DECODE Target: Screens SNPs linked to broad neural development and long-term potentiation complexes (ERICH1, FOX3). Limited by expensive external mass genotyping platforms. | 42695012 |
| 60 | 🔴 Legacy (Clinic Bound) | Image tracking of suspected delayed neuronal death ➔ DECODE Limits: Postoperative CT scan analysis identifying late emergence of low-density areas in a severe trauma casualty. Limited to acute clinical radiologic tracking. | 42695000 |
| 61 | 🟡 Supportive (Clinic Bound) | Kynurenine pathway correlation with cerebellar microstructures ➔ DECODE Target: Traces biophysical neurite orientation dispersion index variations in lobule VIIB via NODDI MRI models. Dependent on specialized laboratory neuroimaging equipment. | 42694864 |
| 62 | 🔴 Legacy (Animal) | Neutrophil extracellular traps and ferroptosis in mice ➔ CLEAR Limits: Investigates post-TBI lipid peroxidation and STING-mediated AMPK dysregulation via PAD4 gene ablation in mice. Confined to preclinical animal tracking. | 42694684 |
| 63 | 🟡 Supportive (Clinic Bound) | Closed-loop brain-computer interfaces for post-stroke loops ➔ SYNC Target: Conceptual review translating motor imagery into contingent electric stimulation loops. Relies on complex clinic-bound decoders and stratified trial models. | 42694671 |
| 64 | 🔴 Legacy (Out of Scope) | Narrative review of brain injury post-cardiopulmonary bypass ➔ DECODE Limits: Traces systemic inflammatory responses and microembolism variations during cardiovascular surgeries. Lacks direct chronic care deployment assets. | 42694590 |
| 65 | 🔴 Legacy (Animal) | Engineered MSCs for targeted P2X7 purinergic blockade ➔ CLEAR Limits: Tracks intra-arterial delivery of iron oxide nanoparticle-labeled stem cells via 9.4 T SWI MRI in mice. Restricted to preclinical animal surgery settings. | 42694507 |
| 66 | 🔴 Legacy (Out of Scope) | Mechanistic review of emerging cell death modalities ➔ CLEAR Limits: Evaluates cuproptosis, disulfidptosis, and PANoptosis signaling network cross-talk in acute stroke paths. Does not supply active clinical recovery logic. | 42694396 |
| 67 | 🔴 Legacy (Clinic Bound) | Prospective validation of the rSIG trauma scoring tool ➔ GUIDE Limits: Evaluates the reverse shock index multiplied by GCS to predict early emergency transfusion needs. Restricted to acute trauma surgery triage settings. | 42694200 |
| 68 | 🟡 Supportive (Clinic Bound) | Three-dimensional computational human head modeling of blast injury ➔ DECODE Target: In silico investigation using ConWep techniques to calculate MPSR and strain loads in the corpus callosum. Restricted to digital engineering simulation environments. | 42694169 |
| 69 | 🔴 Legacy (Animal) | Vortioxetine downstream signaling pathways in mice ➔ PRIME Target: Analyzes hippocampal SIK2/CRTC1 gene expression and transcription cascades following social defeat stress. Confined to a preclinical rodent framework. | 42694140 |
| 70 | 🟡 Supportive (Clinic Bound) | Longitudinal immune profiling after subarachnoid hemorrhage ➔ DECODE Target: Tracks circulating MAIT-cell reductions and serum IL-6/IL-18 cytokine trajectories via flow cytometry. Tied to complex laboratory blood analysis arrays. | 42694134 |
| 71 | 🟡 Supportive (Clinic Bound) | Ultrasound-guided chest physiotherapy protocol for sTBI ➔ GUIDE Target: Clinical validation of lung ultrasound scoring metrics to optimize pulmonary care and reduce NICU stay durations. Dependent on hospital ICU nursing infrastructure. | 42694040 |
| 72 | 🟡 Supportive (Clinic Bound) | Retrospective analysis of P1NP bone turnover biomarkers ➔ DECODE Target: Associates baseline procollagen type I N-terminal propeptide with 12-week heterotopic ossification risk metrics. Dependent on formal clinical lab processing. | 42693786 |
| 73 | 🟡 Supportive (Clinic Bound) | Triple-blind randomized protocol for bilateral tDCS + CIMT ➔ SYNC Target: HAND-IN trial protocol combining transcranial direct current stimulation with constraint training to improve hand scores. Locked inside a clinical trial tracking framework. | 42693609 |
| 74 | 🔴 Legacy (Animal) | Nrsn1-Smarcc1 coupling in post-stroke neural stem cells ➔ UPDATE Limits: Details Foxa2 transcriptional activation and Smarcc1 nuclear translocation via mouse MCAO modeling. Confined to prehistoric animal genetic screening. | 42693582 |
| 75 | 🔴 Legacy (Clinic Bound) | Clinical uptake tracking of magnesium sulfate guidelines ➔ GUIDE Limits: Retrospective electronic chart review tracking MgSO4 administration rates across Danish obstetric networks. Limited to hospital labor environments. | 426 magnesium sulfate |
| 76 | 🔴 Legacy (Animal) | In vivo transfection protocol of flag-HDAC4 in mice ➔ DECODE Target: Outlines stereotaxic intracranial injections into the dentate gyrus to track BrdU+ and Nestin+ cell proliferation. Restricted to lab animal operations. | 42692758 |
| 77 | 🔴 Legacy (Animal) | Epigenetic modeling of the liver-brain metabolic axis ➔ DECODE Limits: Outlines high-fat diet regimens in mice alongside 3D co-cultures to evaluate neuroinflammation. Restricted to preclinical laboratory bench science. | 42692753 |
| 78 | 🟡 Supportive (Clinic Bound) | Multimodal microglial analysis in organotypic slices ➔ CLEAR Target: Standardizes X-ray and heavy-ion radiation evaluation using human patient-derived brain tumor cultures (PDTCs). Dependent on advanced lab culture installations. | 42692558 |
| 79 | 🔴 Legacy (Clinic Bound) | Retrospective analysis of neonatal MRI during hypothermia ➔ DECODE Limits: Assesses injury severity patterns in newborns with hypoxic-ischemic encephalopathy during clinical cooling. Bound to specialized acute neonatal ICU wards. | 42692143 |
| 80 | 🟡 Supportive (Clinic Bound) | Prospective tracking of acute post-concussion emotional symptoms ➔ GUIDE Target: Long-term pediatric concussion assessment mapping parent/child report data to model emotional dysfunction trajectories. Relies on clinical emergency department tools. | 42692005 |
| 81 | 🔴 Legacy (Out of Scope) | Medical biography of a pediatrician with cerebral palsy ➔ GUIDE Limits: Descriptive personal narrative detailing historical lived professional experience within disability care structures in Japan. | 42692032 |
| 82 | 🟡 Supportive (Clinic Bound) | Statistical phenotypic paradigm for cerebral palsy genomics ➔ DECODE Target: Resolves causal variant attribution discrepancies via whole-genome sequencing datasets across a 460-child cohort. Tied to high-cost clinical genomic tools. | 42692005 |
| 83 | 🟡 Supportive (Clinic Bound) | 3D ultrasonography of GM morphology post-Vulpius lengthening ➔ CEMENT Target: Tracks passive ankle range changes alongside muscle belly and fascicle shortening via ultrasound kinetic indices. Dependent on clinical orthopedic laboratories. | 42691845 |
| 84 | 🔴 Legacy (Out of Scope) | Systematic review of interventions for sleep disorders in CP ➔ GUIDE Limits: Abstract-level entry missing core analysis text; focuses on standard review collections of clinical pharmacological and manual sleep targets. | 42691322 |
| 85 | 🔴 Legacy (Out of Scope) | Argentine Cerebral Palsy Register risk factor co-occurrence ➔ DECODE Limits: Regional cross-sectional data documenting associations between preterm demographics, low birthweight, and poor socioeconomic factors. | 42691314 |
| 86 | 🔴 Legacy (Animal) | Cognitive changes evaluated via weight-drop TBI models ➔ DECODE Limits: Screens spatial learning variations in male and female mice using Barnes maze tests post-injury. Confined to preclinical behavior testing. | 42691270 |
| 87 | 🔴 Legacy (Animal) | Chronic dasatinib + quercetin senolytic therapy in rats ➔ UPDATE Limits: Details common carotid stenosis models paired with senolytic infusions to calculate spreading depolarization drops. Confined to invasive animal research. | 42691218 |
| 88 | 🟡 Supportive (Clinic Bound) | Smartphone camera computer vision system for neonatal jaundice ➔ DECODE Target: deploys adaptive median filters and TCN models via optimization loops to classify bilirubin skin color changes. Limited to early neonatal screening targets. | 42690901 |
| 89 | 🟡 Supportive (Clinic Bound) | Review of neuroplasticity in orthodontics and myofunctional therapy ➔ SYNC Target: Structural neurophysiological framework mapping cranial nerve activation during chewing and swallowing. Lacks dedicated digital processing code. | 42690113 |
| 90 | 🟡 Supportive (Clinic Bound) | Ultrasonography of upper limb muscle deformities in spastic CP ➔ CEMENT Target: Evaluates muscle thickness and cross-sectional areas of the biceps brachii across Zancolli classification grades. Tied to hospital diagnostic ultrasound tools. | 42690013 |
| 91 | 🟡 Supportive (Clinic Bound) | Divergent adaptation framework for pediatric vs. adult TBI ➔ DECODE Target: Traces age-stratified shifts in the BDNF-miRNA repair network, gut axes, and CSF dynamics. Lacks automated data extraction software architecture. | 42689994 |
| 92 | 🟡 Supportive (Clinic Bound) | Phase-specific immune-metabolic framework for stroke recovery ➔ CLEAR Target: Conceptualizes chronic neuroinflammation as a time-dependent target loop linked to gut dysbiosis metrics. Lacks direct clinical code tools. | 42689993 |
| 93 | 🟡 Supportive (Clinic Bound) | Temporal precision medicine framework for neurorestoration ➔ TUNE Target: Conceptual dynamic roadmap aligning M1-to-M2 microglial transitions with phase-matched biomarkers. Lacks primary software engineering data. | 42689982 |
| 94 | 🟡 Supportive (Clinic Bound) | Cochrane review update of magnesium sulphate neuroprotection ➔ GUIDE Target: Comprehensive global synthesis of RCT data confirming reduced cerebral palsy incidence up to two years corrected age. Limited to standard clinical data pooling. | 42689525 |
| 95 | 🟡 Supportive (Clinic Bound) | Cochrane systematic review of multisensory infant stimulation ➔ GUIDE Target: Meta-analysis tracking weight changes and CP outcomes post-intervention compared to standard neonatal settings. Relies on low-certainty surrogate metrics. | 42689503 |
| 96 | 🔴 Legacy (Animal) | Melatonin neuroprotection pathways in neonatal HIBD ➔ FUEL Limits: Tracks the TXNIP/Trx-1/GPX4 axis in neuronal ferroptosis via oxygen-glucose deprivation models in PC12 cells and neonatal rats. Preclinical framework. | 42689369 |
| 97 | 🔴 Legacy (Animal) | Small interfering RNA inhibition of B7-H3 after stroke ➔ CLEAR Limits: Tracks acute blood-brain barrier disruption and functional motor changes via 9.4-T magnetic resonance scanner logs in mice. Restricted to animal surgery models. | 42689339 |
| 98 | 🟡 Supportive (Clinic Bound) | Nationwide cohort study of routine dental scaling in spastic CP ➔ GUIDE Target: Population-level database tracking links between professional biofilm removal, pneumonia incidence, and mortality risk reductions. Restricted to clinical dental databases. | 42688963 |
| 99 | 🔴 Legacy (Out of Scope) | Venous thromboembolism prophylaxis guidelines in TBI ➔ GUIDE Limits: Abstract-level entry missing comprehensive tracking data; restricted to acute hospital inpatient medical prophylactic logic. | 42688963 |
| 100 | 🟡 Supportive (Clinic Bound) | Review of stellate ganglion blocks for autonomic dysfunction ➔ TUNE Target: Evaluates ultrasound-guided local anesthetic injections to suppress locus coeruleus circuits in PTSD and stroke conditions. Confined to clinical surgical suites. | 42688769 |
| 101 | 🔴 Legacy (Out of Scope) | Narrative review of pediatric secondary TBI mechanisms ➔ FUEL Limits: Synthesizes existing literature on excitotoxicity, mitochondrial failure, and oxidative injury. Lacks primary empirical datasets or software code. | 42688671 |
| 102 | 🔴 Legacy (Out of Scope) | Qualitative study on psychosocial needs of couples post-TBI ➔ GUIDE Limits: In-depth face-to-face clinical interviews with professionals in India identifying macro-level education and financial themes. Retrospective qualitative methodology. | 42688541 |
| 103 | 🟡 Supportive (Clinic Bound) | Literature review of physical exercise augmentation for PTSD ➔ TUNE Target: Conceptual synthesis mapping aerobic and resistance regimens to transient BDNF elevations and fear extinction loops. Lacks active digital optimization tools. | 42688498 |
| 104 | 🔴 Legacy (Animal) | Secondhand smoke exposure effects on cardiac vagal neurons ➔ CLEAR Limits: Whole-cell patch-clamp electrophysiology assessing action potential thresholds and SK channels in mouse brain slices. Preclinical animal research. | 42688445 |
| 105 | 🔴 Legacy (Clinic Bound) | Intravenous levetiracetam rescue for post-TBI hiccups ➔ TUNE Limits: Clinical case track detailing successful pharmacologic resolution of refractory hiccups in an intensive care setting. Restricted to acute inpatient drug delivery. | 42688418 |
| 106 | 🟡 Supportive (Clinic Bound) | Spinal cord stimulation hypothesis for post-stroke aphasia ➔ SYNC Target: Conceptual blueprint proposing eSCS, tsDCS, and tsPCS to alter cortical connectivity via spinal-cortical loops. Lacks direct hardware code integration. | 42688335 |
| 107 | 🔴 Legacy (Out of Scope) | Retrospective histopathological study of mechanical asphyxia ➔ DECODE Limits: Postmortem cell counts of routine hematoxylin and eosin-stained autopsy lung tissue segments across forensic files. Strictly confined to legal medicine pathology. | 42688292 |
| 108 | 🔴 Legacy (Animal) | Oral boldine administration in blast injury rat models ➔ CLEAR Limits: Tracks microglial process retraction reductions, mGluR2 metrics, and hippocampal transcriptomics in exposed rodents. Limited to preclinical animal models. | 42687969 |
| 109 | 🔴 Legacy (Animal) | Biomechanical motion fidelity scaling in a large animal model ➔ DECODE Limits: Manual and DeepLabCut tracking of angular velocities during rotational acceleration head injuries in pigs. Preclinical mechanical modeling. | 42687961 |
| 110 | 🔴 Legacy (Clinic Bound) | Clinical variables predicting antiseizure medication prescription ➔ GUIDE Limits: Multivariable logistic regression mapping inpatient and discharge ASM dosing patterns across two clinical Level I trauma registries. | 42687937 |
| 111 | 🟡 Supportive (Clinic Bound) | Multi-site analytical validation of multiplexed immunoassay ➔ DECODE Target: Characterizes intra-plate variability, precision, and accuracy metrics of the S-PLEX Human Neurology Panel for GFAP, NF-L, and Tau. Restricted to advanced clinical laboratory equipment. | 42687911 |
| 112 | 🔴 Legacy (Out of Scope) | Neuroethical framework introducing liminal personhood ➔ GUIDE Limits: Conceptual philosophical discourse advocating for dignity-conserving care models at the edges of consciousness. Contains no objective biological or digital targets. | 42687580 |
| 113 | 🟡 Supportive (Clinic Bound) | Bayesian latent growth modeling of post-ABI alexithymia ➔ DECODE Target: Traces Perth Alexithymia trajectories alongside longitudinal depression scales over a 24-month clinical follow-up. Relies entirely on manual psychometric tracking. | 42687530 |
| 114 | 🟡 Supportive (Clinic Bound) | Neuropsychological empathy motivation task profiling ➔ DECODE Target: Lesion group comparison study assessing off-line cognitive empathy parameters in patients with vmPFC damage. Restricted to clinical laboratory experimental settings. | 42687436 |
| 115 | 🔴 Legacy (Animal) | Modular Prussian blue nanozyme microneedle platforms ➔ CLEAR Limits: Low-temperature drying process fabricating HA/curcumin delivery matrices tested in acute rodent TBI models. Preclinical nano-formulation research. | 42687244 |
| 116 | 🔴 Legacy (Clinic Bound) | Scoping review of penetrating dural venous sinus injuries ➔ GUIDE Limits: Descriptive synthesis of isolated case reports tracking segment-specific surgical ligation versus posterior SSS reconstruction. Strictly limited to acute neurosurgical tables. | 42687051 |
| 117 | 🟡 Supportive (Clinic Bound) | Literature review of exercise-induced neuropeptidergic neuroadaptation ➔ TUNE Target: Heuristic maps detailing biphasic dopamine, serotonin, and orexin loop adjustments across human and animal data. Contains no digital processing platform data. | 42687004 |
| 118 | 🟡 Supportive (Clinic Bound) | Visual and automated plausibility screening of high-frequency TBI logs ➔ DECODE Target: Multi-step algorithm testing osmotherapy physiological signatures (ICP > 20 mm Hg) inside the CENTER-TBI registry dataset. Dependent on high-density clinical ICU telemetry loops. | 42686990 |
| 119 | 🔴 Legacy (Animal) | Astrocyte-specific P2Y1R-overexpressing transgenic mouse model ➔ DECODE Limits: Traces neuronal hyperexcitability and IGFBP2 synaptic transmission changes via dual-color Ca2+ imaging and CRISPR knockdowns in rodents. Preclinical genetics. | 42686546 |
| 120 | 🔴 Legacy (Out of Scope) | Narrative overview of degenerative cervical myelopathy ➔ SYNC Target: Pathobiological description of time-sensitive compression windows and structural decompression effects. Lacks distinct real-time digital re-wiring mechanisms. | 42686277 |
| 121 | 🔴 Legacy (Out of Scope) | Pathobiology summary of chronic spinal cord compression loops ➔ DECODE Limits: Narrative overview tracing microglial activation, local ischemia, and generic gut-spinal axis inflammation concepts. | 42686276 |
| 122 | 🟡 Supportive (Clinic Bound) | Pilot randomized trial of early melatonin for pediatric sleep ➔ GUIDE Target: Feasibility trial tracking 30-day SDSC T-scores and home actigraphy counts started within 72 hours of injury. Lacks direct software loop implementation. | 42686209 |
| 123 | 🟡 Supportive (Clinic Bound) | Systematic review of functional brain adaptations in RSI ➔ DECODE Target: Voxel-based morphometry review mapping increased sensorimotor and prefrontal cortex functional connectivity. Dependent on high-cost clinical neuroimaging infrastructure. | 42686158 |
| 124 | 🔴 Legacy (Animal) | Behavioural and telencephalic transcriptomics in European seabass ➔ DECODE Limits: Inhibitory control cylinder tests paired with telencephalic gene expression profile mapping in juvenile fish. Preclinical marine biological study. | 42686047 |
| 125 | 🔴 Legacy (Out of Scope) | Postmortem histopathology of a middle ear cholesteatoma ➔ DECODE Limits: Temporal bone specimen anatomy log demonstrating epithelial matrix variations following terminal hypoxic brain injury. Limited to forensic microscopy. | 42685350 |
| 126 | 🟡 Supportive (Clinic Bound) | Cross-sectional diffusion MRI analysis of corpus callosum profiles ➔ DECODE Target: Propensity score-matched study inside UK Biobank mapping FA and MD metric variations against menopause timing. Dependent on massive clinical neuroimaging databases. | 42685146 |
| 127 | 🟡 Supportive (Clinic Bound) | Characterization of the military Nutrition and TBI Data Repository ➔ DECODE Target: Longitudinal registry integration extracting encounter, lab, and pharmacy data fields across 431,673 patients. Restricted to large-scale institutional military health records. | 42685041 |
| 128 | 🔴 Legacy (Out of Scope) | Review of osteopontin cellular actions in brain aging ➔ CLEAR Limits: Synthesizes contradictory literature findings on microglia priming and perivascular SPP1 expression levels without introducing novel operational code. | 42684942 |
| 129 | 🔴 Legacy (Out of Scope) | Quality improvement initiative for deceased organ donation ➔ GUIDE Limits: Nurse-driven practice audit tracking structured inpatient processes and organ procurement timing metrics within the ICU. Out of scope for neuro-rehabilitation. | 42684875 |
| 130 | 🟡 Supportive (Clinic Bound) | PCA dimension-reduction modeling of neural exposome burden ➔ DECODE Target: Prospective analysis calculating PC1 burden scores from exogenous, endogenous, and behavioral variables to stratify 6-month MoCA recovery. Requires institutional clinic tracking inputs. | 42684866 |
| 131 | 🔴 Legacy (Animal) | Nitric oxide synthase inhibitor testing in juvenile piglets ➔ CLEAR Limits: Tracks TUNEL-positive hippocampal cells and microglial neuroinflammation post-DHCA using 2-iminobiotin infusions. Confined to invasive large animal research. | 42684802 |
| 132 | 🟡 Supportive (Clinic Bound) | Retrospective case series of antemortem neuropsychological CTE profiles ➔ DECODE Target: Characterizes z-score memory and executive performance impairments matched against postmortem p-tau burden across 11 brain regions. Restricted to autopsy-correlated clinical registries. | 42684699 |
| 133 | 🔴 Legacy (Out of Scope) | Meta-analysis of balloon atrial septostomy in neonates ➔ DECODE Limits: Pooled odds ratio meta-analysis assessing mortality and pre-operative intubation frequencies in d-TGA congenital cardiac operations. | 42684480 |
| 134 | 🟡 Supportive (Clinic Bound) | Usability trial of a serious game waiter simulation for ED ➔ DECODE Target: Theory-driven digital platform tracking planning, working memory, and multitasking metrics in a virtual restaurant layout. Relies on extensive clinical neuropsychological benchmarking. | 42684412 |
| 135 | 🟡 Supportive (Clinic Bound) | Systematic review and eye-movement recording analysis of AAN ➔ DECODE Target: Quantifies slow-phase velocities and bithermal caloric response asymmetries to differentiate peripheral vs. central vestibular variants. Dependent on medical laboratory testing labs. | 42683799 |
| 136 | 🔴 Legacy (Out of Scope) | Systematic review of caregiver interventions in LMICs ➔ GUIDE Limits: Fair-to-good qualitative studies compiling South Asian group-based child motor parameters and caregiver well-being scales. Replaces active telemetry with manual oversight. | 42683689 |
| 137 | 🔴 Legacy (Clinic Bound) | Case report of penetrating cranio-cerebral gunshot wound ➔ GUIDE Limits: Emergency craniotomy protocols tracking surgical preservation of the superior sagittal sinus post-ballistic trauma. Bound to acute emergency neurosurgical intervention suites. | 42683368 |
| 138 | 🔴 Legacy (Animal) | Trigonelline evaluation in binge ethanol mouse models ➔ CLEAR Limits: Tracks iNOS/NO, TLR4, and caspase-3 apoptotic protein levels via chemical gavage and tissue dissection in male mice. Confined to preclinical animal toxicology. | 42683307 |
| 139 | 🟡 Supportive (Clinic Bound) | Scoping review of cortical reorganization tracking in PLP ➔ TUNE Target: Synthesizes M1/S1 sensorimotor modifications during mirror therapy, augmented reality, and brain stimulation protocols via fMRI/EEG. Bound to technical institutional lab architectures. | 42683185 |
| 140 | 🟡 Supportive (Clinic Bound) | Metagenomic sequencing and serum cytokine profiling in acute TBI ➔ PRIME Target: Tracks alpha diversity drops, Faecalibacterium prausnitzii depletion, and serum TNF-α shifts within 7 days post-injury. Limited by complex shotgun metagenomic setups. | 42682993 |
| 141 | 🔴 Legacy (Out of Scope) | Editorial introducing brain injury cross-system interactions ➔ DECODE Limits: High-level introductory editorial text lacking primary quantitative data metrics, software frameworks, or distinct empirical methodologies. | 42682594 |
| 142 | 🔴 Legacy (Animal) | Public scRNA-seq re-analysis and in vitro validation of TBI ➔ DECODE Limits: Tracks CellChat MIF-ACKR3 communication vectors using bone marrow-derived surrogates and bEnd.3 cells. Preclinical cell culture framework. | 42682555 |
| 143 | 🟡 Supportive (Clinic Bound) | Conceptual review of the bidirectional glymphatic brain-lung axis ➔ CLEAR Target: Traces AQP4 polarization loss, neurogenic toxin spillover vectors, and microvascular TLR4 receptor binding models. Contains no primary digital hardware architectures. | 42682458 |
| 144 | 🔴 Legacy (Out of Scope) | Editorial text on adaptation mechanisms post-spinal cord injury ➔ UPDATE Limits: Short introductory commentary lacking specialized empirical research tables, code scripts, or operational patient data profiles. | 42682409 |
| 145 | 🟡 Supportive (Clinic Bound) | Comprehensive review of repetitive transcranial magnetic stimulation ➔ TUNE Target: Maps rTMS parameter ranges and motor cortex localization rules for pain and depression rehabilitation. Confined to standard laboratory neuromodulatory layouts. | 42682227 |
| 146 | 🟡 Supportive (Clinic Bound) | Multicenter external validation of continuous iICP algorithms ➔ DECODE Target: Validates a dynamic calculation algorithm tracking individualized intracranial pressure insult doses using the high-resolution CAHR-TBI database. Tied to neurocritical care ICU monitors. | 42681854 |
| 147 | 🟡 Supportive (Clinic Bound) | Descriptive retrospective study of awake craniotomy mappings ➔ DECODE Target: Tracks transient postoperative functional decline via KPS, GCS, and MMSE scores following direct electrical stimulation mapping. Bound to complex surgical theater neuro-mapping suites. | 42681670 |
| 148 | 🔴 Legacy (Out of Scope) | State-of-the-science review compilation index ➔ DECODE Limits: General journal review index or editorial collection summary text completely missing novel experimental architectures, statistics, or software code blueprints. | 42681582 |
| 149 | 🟡 Supportive (Clinic Bound) | Indirect disconnection mapping pipeline protocol ➔ DECODE Target: Practical step-by-step pipeline integrating MRIcron, BCBtoolkit, FSL, and SPM12 to infer white matter tract disruption from structural datasets. Requires high-cost clinical neuroimaging computer pipelines. | 42681302 |
| 150 | 🔴 Legacy (Animal) | Chemogenetic activation tracking of the IL-RE-vHIPP circuit ➔ PRIME Target: Maps rapid top-down control over long-term potentiation deficits and structural plasticity in mouse depression models. Confined to preclinical animal genetics. | 42680757 |
| 151 | 🔴 Legacy (Animal) | Electron microscopy analysis of callosal axon ultrastructure ➔ DECODE Limits: Measures axonal g-ratios and phagolysosome-bearing cell densities in young vs. 12-month-old mice 3 months post-injury. Preclinical animal anatomy. | 42680156 |
| 152 | 🔴 Legacy (Animal) | Group ICA resting-state fMRI tracking in a porcine model ➔ TUNE Limits: Controlled cortical impact targeting the motor cortex of pigs to monitor sensory-motor network compensation. Restricted to translational large animal infrastructure. | 42679942 |
| 153 | 🟡 Supportive (Clinic Bound) | Diagnostic yield evaluation of routine vs. continuous EEG ➔ DECODE Target: Prospected screening comparing 30-minute rEEG, 1-hour EEG, and 24-hour cEEG for interictal discharge capturing. Bound to acute neuro-ICU diagnostic beds. | 42679941 |
| 154 | 🔴 Legacy (Animal) | Medial ganglionic eminence-derived interneuron mapping ➔ UPDATE Limits: Tracks PV+ interneuron maturational arrest, dendritic simplification, and patch-clamp mIPSC amplitudes in post-HI mice. Confined to preclinical cellular biology. | 42679940 |
| 155 | 🔴 Legacy (Animal) | Oleic acid regulation of PPARγ pathways in mice ➔ CLEAR Limits: Intracerebral collagenase injections paired with GW9662 antagonist infusions to track microglial polarization shifts in rodents. Preclinical mechanical modeling. | 42679938 |
| 156 | 🟡 Supportive (Clinic Bound) | Triple-blind randomized pilot trial of Citicoline ➔ UPDATE Target: Evaluates 90-day functional recovery and MMSE cognitive outcomes using 1000 mg/day oral administration post-TBI. Requires structured, manual neuropsychological tests. | 42679920 |
| 157 | 🟡 Supportive (Clinic Bound) | Review of mechanosensitive Piezo1 and Piezo2 channels ➔ PRIME Target: Maps neuroinflammatory barrier pathways and tumor mechanosignaling markers to direct drug discovery. Lacks home-deployable hardware logic interfaces. | 42679748 |
| 158 | 🟡 Supportive (Clinic Bound) | Population survey tracking healthcare access for pediatric TBI ➔ GUIDE Target: Cross-sectional screening of National Survey data mapping developmental speech disorders and parent strain metrics. Relies on subjective caregiver self-report metrics. | 42679682 |
| 159 | 🟡 Supportive (Clinic Bound) | Scoping review of neurosurgical venous thromboembolism ➔ GUIDE Target: Compiles New Zealand consensus guidelines for pairing intermittent pneumatic compression with early LMWH scheduling. Strictly limited to hospital inpatient surgical units. | 42679658 |
| 160 | 🟡 Supportive (Clinic Bound) | Gaussian network analysis of comorbidities in IPV survivors ➔ DECODE Target: Maps connectivity, influence, and bridge symptoms (worthlessness, jumpiness) across a multi-site 300-woman sample. Dependent on complex mathematical clustering models. | 42679623 |
| 161 | 🔴 Legacy (Clinic Bound) | 20-year retrospective analysis of universal helmet law repeal ➔ GUIDE Limits: Evaluates emergency department admission logs and on-scene fatality rates linked to severe head trauma across decades. Confined to macro-level public policy tracking. | 42679513 |
| 162 | 🟡 Supportive (Clinic Bound) | Hemodynamic screening using static head-up-t tilts ➔ TUNE Target: Measures heart rate, blood pressure, and stroke volume variations during dynamic tilt-translation sled tests. Dependent on high-cost balance-lab machinery. | 42678939 |
| 163 | 🟡 Supportive (Clinic Bound) | Instrumented gait analysis tracking Lokomat RAGT and PT ➔ GUIDE Target: Assesses Gait Profile Scores and joint-specific kinematic vectors across a 20-day severity-stratified pediatric cohort. Dependent on robotic hospital infrastructure. | 42678908 |
| 164 | 🔴 Legacy (Out of Scope) | Qualitative evaluation of carer-led training in rural Malawi ➔ GUIDE Limits: In-depth interviews interpreted via the Consolidated Framework for Implementation Research to track community logistics. Replaces active telemetry with manual logs. | 42678614 |
| 165 | 🟡 Supportive (Clinic Bound) | Operational review of an urban transdisciplinary concussion model ➔ GUIDE Target: Outlines interdisciplinary cross-specialty collaboration infrastructure and infrastructure workflows across a decade. Lacks standalone home engineering assets. | 42678583 |
| 166 | 🟡 Supportive (Clinic Bound) | Multivariable analysis of age-related platelet dynamics ➔ DECODE Target: Tracks impedance aggregometry and viscoelastic clotting changes up to 7 days post-trauma across 716 patients. Restricted to advanced hospital hematology laboratories. | 42678571 |
| 167 | 🔴 Legacy (Animal) | Rat cardiopulmonary bypass model of Harlequin syndrome ➔ DECODE Limits: Measures plasma enolase, S100B, and regional cerebellum edema under retrograde femoral vs. anterograde carotid perfusion loops. Preclinical surgical trial. | 42678380 |
| 168 | 🔴 Legacy (Animal) | Affective-like forced-swim screening post-Temozolomide ➔ CLEAR Limits: Tracks NeuroD neural progenitor depletion and hippocampal FADD alterations across chemotherapeutic injection cycles in rats. Confined to preclinical lab work. | 42678240 |
| 169 | 🔴 Legacy (Animal) | RNA sequencing of prefrontal cortex tissue in TBI rats ➔ DECODE Target: Maps Nts/Ntsr1 and Drd1 neuroimmune remodeling signatures following paired rTMS and press-tack needle protocols. Confined to preclinical rodent transcriptomics. | 42677979 |
| 170 | 🔴 Legacy (Out of Scope) | Retrospective medical triage analysis of historical plane crash ➔ GUIDE Limits: Historical cohort review profiling field triage, high-altitude exposure, and extreme starvation triage patterns. Out of scope for contemporary neuro-repair tracking. | 42677640 |
| 171 | 🔴 Legacy (Animal) | Microglia-specific Lilrb4 knockout mouse profiling ➔ CLEAR Limits: Deactivates the STING/RIPK3 axis to map microglial necroptosis and neuroinflammation volumes post-tMCAO. Limited to preclinical transgenic rodent engineering. | 42677054 |
| 172 | 🔴 Legacy (Out of Scope) | Qualitative interviews using the Community Cultural Wealth model ➔ GUIDE Limits: Surveys 8 Black TBI survivors and 6 caregivers to capture institutional insurance navigation barriers and social capital themes. Retrospective sociology. | 42676860 |
| 173 | 🔴 Legacy (Animal) | Trigeminal subnucleus neuroplasticity mapping in rats ➔ TUNE Limits: Tracks calbindin D28K positive neurons and 5HT-T varicosity lengths following dental pulpitis and oral paracetamol delivery. Confined to lab animal models. | 42676687 |
| 174 | 🔴 Legacy (Out of Scope) | Bespoke survey assessing staff management of confabulation ➔ GUIDE Limits: Captures clinical acceptability metrics of ‘playing along’ techniques via convenience sampling across dementia and brain injury wards. Manual self-report methodology. | 42676562 |
| 175 | 🔴 Legacy (Animal) | Lycopene modulation of cGAS-STING pathways in mice ➔ CLEAR Limits: Screens spatial learning drops, MEHP-induced M1 polarization, and mitochondrial structural defects across 28-day gavage cycles in mice. Preclinical toxicology. | 42676497 |
| 176 | 🟡 Supportive (Clinic Bound) | Narrative synthesis of moderate-to-vigorous exercise for depression ➔ TUNE Target: Combines myokine signaling concepts and school-based digital mental health frameworks to build precision psychiatry models. Lacks stand-alone tracking code. | 42676354 |
| 177 | 🟡 Supportive (Clinic Bound) | Validation of the i-STAT TBI point-of-care cartridge ➔ DECODE Target: Deploys an ED throughput calculator to assess GFAP/UCH-L1 sensitivity metrics against head CT overuse indices. Dependent on institutional trauma center labs. | 42676168 |
| 178 | 🔴 Legacy (Clinic Bound) | Retrospective descriptive audit of cranial CT scans in Nigeria ➔ DECODE Limits: Traces injury mechanics, scalp swelling, and cerebral contusion percentages across a 183-patient registry. Limited to static hospital medical record mining. | 42676036 |
| 179 | 🟡 Supportive (Clinic Bound) | Latent class growth modeling of albumin-to-RDW trajectories ➔ DECODE Target: Deploys ExtraTrees machine-learning classifiers and SHAP web research tools to evaluate multi-site ARR mortality hazards. Dependent on ICU database sets (MIMIC-IV). | 42675994 |
| 180 | 🟡 Supportive (Clinic Bound) | Review of stem cell and cell-free extracellular vesicle engineering ➔ UPDATE Target: Summarizes immune microenvironment remodeling, biomaterial-assisted delivery systems, and nano-platforms. Lacks standalone architectural scripts or hardware templates. | 42675872 |
| 181 | 🟡 Supportive (Clinic Bound) | Nanomaterial-enhanced biosensor performance review ➔ DECODE Target: Synthesizes dynamic ranges and detection limits (GFAP 22 pg/mL, UCH-L1 327 pg/mL) across gold nanoparticle and graphene devices. Limited to lab-based buffer validations. | 42675571 |
| 182 | 🟡 Supportive (Clinic Bound) | fNIRS monitoring of combined sensory-motor interventions ➔ SYNC Target: deconstructs wavelet amplitude and phase coherence metrics (0.01-0.08 Hz) to measure cortical network synchronization during PES-BAT. Dependent on high-cost lab rigs. | 42675513 |
| 183 | 🔴 Legacy (Animal) | Microarray analysis of frontal cortex gene expression in mice ➔ DECODE Limits: Tracks coordinated upregulation of Drd2, Adora2a, and Egr2 during naloxone-precipitated morphine withdrawal cycles. Preclinical addiction framework. | 42675309 |
| 184 | 🟡 Supportive (Clinic Bound) | Narrative overview of phase-matched TBI pharmacology modules ➔ TUNE Target: Organizes amantadine and hypertonic sodium lactate parameters across a modular framework blueprint. Contains no standalone digital logic validation code. | 42675200 |
| 185 | 🔴 Legacy (Out of Scope) | Scoping review of paid employment drops in adults with CP ➔ GUIDE Limits: Categorizes cross-sectional body functions and accessibility factors across 29 global registries using qualitative ICF framework coding matrices. | 42674772 |
| 186 | 🟡 Supportive (Clinic Bound) | EXTRACCT blast injury clinical practice guidelines ➔ GUIDE Target: Stratifies surgical decompressive craniectomy thresholds and pupillometry tracking schedules across variable resource environments. Restricted to institutional field hospital deployment teams. | 42674601 |
| 187 | 🟡 Supportive (Clinic Bound) | Prospective tracking of 1-year TBI Model Systems logs ➔ GUIDE Target: Employs multivariable models to map PHQ-9 depressive symptom fields against 5-year all-cause mortality indicators. Relies on legacy multi-center health registries. | 42674341 |
| 188 | 🔴 Legacy (Out of Scope) | Editorial highlight index of developmental and neuroplastic frameworks ➔ DECODE Limits: High-level overview sheet reviewing international terminology shifts (F-words, E-words) completely devoid of baseline clinical tracking statistics. | 42674337 |
| 189 | 🟡 Supportive (Clinic Bound) | MRI ventricular volume segmentation tracking biomechanical load ➔ DECODE Target: Quantifies left inferior horn enlargement using generalized least squares models in former athletes. Dependent on advanced research imaging databases. | 42674291 |
| 190 | 🟡 Supportive (Clinic Bound) | Sequential multivariable modeling of adolescent cognitive health ➔ DECODE Target: Tracks interactive associations between sleep regularity indices, sports participation, and cognitive difficulties using National Survey fields. Dependent on complex data weights. | 42674262 |
| 191 | 🟡 Supportive (Clinic Bound) | Machine learning-based structural brain age gap calculation ➔ DECODE Target: Tracks transient postpartum subcortical volumetric deviations and SHAP value changes across longitudinal MRI scans. Dependent on institutional imaging scanners. | 42673943 |
| 192 | 🔴 Legacy (Clinic Bound) | 17-year retrospective registry audit of neonatal meconium aspiration ➔ GUIDE Limits: Evaluates incidence rates, PPHN co-occurrences, and mechanical ventilation durations from historical Indian clinical workstations. Confined to hospital ICU logs. | 42673814 |
| 193 | 🟡 Supportive (Clinic Bound) | Longitudinal clinical guidelines for outpatient acquired brain injury care ➔ GUIDE Target: Synthesizes symptom tracking schedules, physical therapy milestones, and tone abnormalities for pediatric providers. Contains no primary software architecture. | 42020792 |
| 194 | 🔴 Legacy (Animal) | Isoquercetin targeting of histone methyltransferase G9a in rats ➔ UPDATE Limits: Deploys MCAO clamping and OGD/R neuronal model metrics to trace H3K9me2 enrichment shifts at the BDNF promoter. Confined to preclinical molecular biology. | 41983275 |
| 195 | 🔴 Legacy (Animal) | Hypoxic-ischemic mouse modeling tracking Tuina mechanisms ➔ SYNC Target: Doubles immunofluorescence stains (Iba1 + GLUT1/COX IV) to track microglial energy metabolism shifts post-injury. Confined to preclinical animal studies. | 41981504 |
| 196 | 🔴 Legacy (Animal) | Whole-transcriptome sequencing of nucleus accumbens in female rats ➔ DECODE Limits: Traces interindividual reward variations and immediate early gene patterns (Egr1, Egr2) via place preference layouts. Preclinical animal genetics. | 41996992 |
| 197 | 🟡 Supportive (Clinic Bound) | Meta-analysis tracking gut-brain short-chain fatty acids ➔ PRIME Target: Random-effects modeling pooling fecal acetate/propionate drops to calculate correlation weights with clinical depression parameters. Dependent on clinical metabolic tracking labs. | 41976937 |
| 198 | 🟡 Supportive (Clinic Bound) | Review of Hydroxysafflower Yellow A mechanisms in stroke ➔ FUEL Target: Compiles cell and animal tissue parameters linking mitochondrial stabilization to stroke-heart syndrome tracking profiles. Lacks primary experimental system deployment code. | 41996399 |
| 199 | 🔴 Legacy (Animal) | Injectable ROS-responsive hydrogel platforms in hemorrhagic stroke ➔ CLEAR Limits: Co-encapsulates IL-4 with PLGA microspheres using focused ultrasound triggering in a rat model. Restricted to preclinical biomaterials engineering. | 41996263 |
| 200 | 🟡 Supportive (Clinic Bound) | Caliper morphometric morphologic screening of digit ratios ➔ DECODE Target: Case-control trial measuring 2D:4D variations across 75 children with CP to screen for prenatal sex-steroid exposures. Relies on simple, manual physical measurements. | 41986144 |
