(pTMS) Transcranial Magnetic Stimulation : WK 33 2026 Horizon Filter | BRIGHT CP Research

Neuroplasticity in Action: How TMS Rewires Brains in Cerebral Palsy / HIE

(pTMS) Transcranial Magnetic Stimulation

A review of 200 new global studies published in the week of August 1oth, 2026 yields zero (0) Additive findings.

However, Study #30 highlights a Supportive study discussing TMS. Also, BRIGHT participated in the 2026 Beijing Brain Conference and sat in on an exciting talk by Dr. Li Fei, on use of TMS for Autism, that seemed to show true gains in speech and social skills.

Executive Summary: Horizon Filter Evaluation – Week 33, Aug 10th, 2026

BRIGHT participated in the 2026 Beijing Brain Conference co-hosted by CIBR and Nature. BRIGHT presented a peer-reviewed poster, introducing its abstract titled “Beyond Top-Down Control: Operationalizing Connectome Circuits for HIE Restoration via The NeuroLoop Protocol”. The poster introduced BRIGHT’s ongoing thinking around long-term functional recovery in HIE/CP, translational neuroscience, and The NeuroLoop Protocol, a neuro-rehabilitation framework currently being explored by BRIGHT. BRIGHT also organized an August 17th, 2026 working session that brought together 10 cross-disciplinary experts from basic research, engineering translation, AI, and clinical practice. On the basic research side, participants included Dr. Yihong Ye, Deputy Director for Academic Affairs and Distinguished Investigator at CIBR; Dr. Don Cleveland, Distinguished Professor at the University of California, San Diego and 2018 Breakthrough Prize in Life Sciences laureate, who was invited to share his extensive experience partnering with patient advocacy organizations to design fast-moving, proactive translational frameworks.

One speaker that completely blew me away at the 2026 Beijing Brain Conference was a major breakthrough by Dr. Li Fei’s team using a new TMS protocol for Autism & co-occurring intellectual disabilities. The before-and-after videos showed clear, objective improvements in speech and social skills. It’s very rare to see actual videos of true improvement in academic papers. A p-value of <0.05 might satisfy a researcher in a lab, but parents don’t care about statistics; they want to see real-world results like better mobility and speech. Dr. Li Fei’s presentation showed before and after videos of children speaking words like “water”. The before and after improvement in clarity of the words was astounding.

I’ve personally experienced TMS before, and Dr. Li’s approach is totally different from the old, uncomfortable protocols. It’s a 5-day program where individual stimulation sessions last only about three minutes—making it incredibly practical and low-burden for families. This isn’t a sales pitch; you can’t buy this treatment right now. It was an elite research presentation at a top global expert forum. But it proves the science is moving.

Cerebral Palsy and autism are different, but the underlying neuroscience and neuroplasticity overlap deeply. Therefore it makes sense for our communities to be working closely together.

For a deeper understanding of Transcranial Magnetic Stimulation and Autism, review Dr. Li Fei’s TMS research directly.

Additionally, Study #30, High-frequency repetitive transcranial magnetic stimulation promotes motor recovery after spinal cord injury associated with spinal-cortical plasticity, demonstrates that high-frequency repetitive transcranial magnetic stimulation (rTMS) promotes locomotor recovery and enhances corticospinal tract remodeling following spinal cord injury in rats. These findings support biological approaches focused on targeted neuromodulation to reconstruct damaged neural circuits and restore motor function.

For the NeuroLoop, TMS fits into the NeuroLoop PRIME domain along side such neuromodulation techniques as taVNS, and specifically for neuromodulation targeting chronic Hypoxic-Ischemic Encephalopathy (HIE) within a closed-loop neuroplasticity rehabilitation framework, pTMS (Paired/Programmable TMS) is theoretically and mechanistically superior to traditional tTMS (Standard/Repetitive Transcranial Magnetic Stimulation).

pTMS (Paired Transcranial Magnetic Stimulation / Personalized TMS) refers to applying precise, timed pairs of magnetic pulses (or pairing a brain pulse with a peripheral nerve pulse, known as Paired Associative Stimulation / PAS). It can also refer to Personalized TMS (PrTMS), which adjusts frequencies based on real-time quantitative EEG (qEEG) data.

Hypoxic-Ischemic Encephalopathy damages the brain because global oxygen deprivation injures complex, integrated circuits rather than just a single localized “spot.” To heal a diffuse injury like HIE, you cannot just broadly blast an area with standard tTMS pulses.

Instead, pTMS uses Paired Associative Stimulation (PAS). By delivering an electrical pulse to a peripheral nerve (like the wrist or ankle) and timing a magnetic pTMS pulse to hit the motor cortex exactly when that peripheral signal arrives in the brain (typically a window of 25 milliseconds), it forces those specific, damaged pathways to re-wire. This utilizes the foundational neuroplastic rule: Hebbian plasticityneurons that fire together, wire together.

A true closed-loop setup requires real-time feedback. Advanced pTMS set-ups link brain mapping (qEEG or live EMG) or motion tacking, directly to the magnetic stimulator. The system tracks the phase of the patient’s internal brain waves (such as the sensorimotor rhythm or alpha cycles) and commands the magnetic pulse to fire only during the peak of that wave. This maximizes the brain’s receptivity to neuroplastic change.

Chronic HIE survivors often display highly disorganized, asymmetric background slow-wave brain activity on an EEG. Personalized pTMS platforms map these unique, distorted frequencies. Instead of forcing a generic 10 Hz treatment on an asymmetric brain, pTMS dynamically adjusts the pulse intervals week-by-week to coax the disorganized HIE brain networks back into a synchronous rhythm.

Several major manufacturers now offer specialized “compact” or “tabletop” research-grade stimulators that skip the massive medical carts and operate entirely on standard 100-240V power. They pack standard clinical-strength rTMS, paired-pulse (pTMS), and Theta Burst (TBS) capabilities into a highly mobile, suitcase-sized footprint. They do not require liquid cooling loops or dedicated high-voltage building circuits, making it possible for TMS to be a realistic modality outside of massive institutions.

Executive Summary: Horizon Filter Evaluation – Week 33, Aug 10th, 2026

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Status

Core Finding & Target Domain

Source / PMID

1

🟡 Supportive (Clinic Bound)

Investigation of brain connectivity alteration in non-severe TBINetwork Mapping Target: Maps visual-limbic network connectivity shifts under emotional load. Disqualified from home use due to reliance on continuous, high-cost clinical SPM12/CONN functional neuroimaging infrastructure.

42571587

2

🟡 Legacy (Out of Scope)

Observable signs of concussion in professional slap fightingVideo Review Limits: Identifies motor incoordination and vacant looks via video protocols. Functions as a descriptive sports tracking tool for acute injury awareness, missing active chronic repair mechanisms.

42571483

3

🟡 Legacy (Genetic Profile)

Whole genome sequencing in cerebral palsy: UK pilot studyStatic Taxonomy: Identifies pathogenic variants in 12.8% of cases to inform genetic prognosis and familial recurrence risk. Relies on static diagnostic profiling without active neuroplastic repair.

42571358

4

🟡 Legacy (Out of Scope)

Visual Snow Syndrome following mild traumatic brain injuryDiagnostic Referral: Outlines a unique post-TBI visual phenomenon requiring specialist ophthalmology referral for differential diagnosis. Provides no scalable home intervention loop.

42571114

5

🟡 Legacy (Acute Phase)

Cerebral High-Frame-Rate Ultrasound Imaging in NICUHyperacute Perfusion Triage: Uses high-frequency plane-wave Doppler to calculate flow indices and evaluate blood flow velocity shifts in neonates with unilateral brain injury. Restricted entirely to acute ICU tracking and pathobiology prevention.

42570928

6

🟡 Legacy (Descriptive Profile)

Posttraumatic epilepsy: Pathophysiology and clinical characteristicsDescriptive Narrative: Reviews lifespan epidemiology, epileptogenesis, and individual risk assessments for long-term sequelae. Fails to introduce any active physical or biological catalyst.

42570370

7

🟡 Legacy (Socio-Vocational)

Critical role of meaningful employment in brain injury rehabVocational Tracking: Explores the impact of purposeful work on self-esteem using manual COPM and BDI scales. Tracks structural transportation barriers without expanding core NeuroLoop protocol architecture.

42570256

8

🟢 Additive (Animal Only)

IL-19(+) monocytes suppress neuroinflammation after TBIActive Catalyst Switch: Identifies a cranial bone marrow-derived monocyte population that limits microglial hyper-responses via the IL-19/IL-20R axis. Disqualified from home translation due to the requirement for invasive intracerebroventricular injections in mice.

42570240

9

🟡 Legacy (Animal Only)

Altered hippocampal lipid profile underlies anxiety secondary to mTBIEarly Pathology Trap: Identifies region-specific diacylglycerol and phospholipid alterations in C57BL/6 mice 48–72 hours post-weight-drop. Far removed from chronic human functional utility.

42570207

10

🟡 Supportive (Invasive)

Pulsed Radiofrequency for Post-Stroke ComplicationsMinimally Invasive Constraint: Reviews PRF neuromodulation for post-stroke pain and motor recovery. Disqualified from home use as it remains a minimally invasive, clinic-bound procedure targeting specific nerves under image guidance.

42570137

11

🟡 Legacy (Acute Phase)

Erratum: Sustained neuronal DNA damage and radiation-induced brain injuryOut of Scope: Historical correction regarding acute blood-brain barrier disruption pathways following cellular radiation damage.

42570001

12

🟡 Legacy (Administrative)

The Open Data Commons for Traumatic Brain Injury PlatformAdministrative Informatics: Describes an interagency community repository and data-sharing behavior for pre-clinical research management. Contains no direct therapeutic loops.

42569911

13

🟡 Legacy (Descriptive Profile)

Functional outcomes and barriers of assistive devices in RwandaDescriptive Profiling: Cross-sectional study matching adapted spoons and orthoses to play skills. Tracks manual device costs and geographic barriers without expanding NeuroLoop hardware architecture.

42569845

14

🟡 Legacy (Administrative)

Temporal trends in post-cardiac arrest brain injury researchBibliometric Analysis: Maps a decade of literature shifting from hypothermia to multimodal prognostication. Serves as academic meta-data with a complete clinical translation gap.

42569436

15

🟡 Supportive (Animal Only)

Nanozyme-based therapeutic strategies for traumatic brain injuryHigh Translational Risk: Reviews oligomeric carbon nanozymes that restore redox homeostasis and preserve cerebral perfusion in preclinical models. Disqualified from home scaling due to unverified human safety and early-stage animal data.

42569353

16

🟡 Legacy (Acute Phase)

Out-of-hospital cardiac arrest with unusual cardiac anatomyEmergency Care Window: Case study of a Fontan circulation arrest resulting in diffuse hypoxic injury and care withdrawal. Restricted entirely to hyperacute resuscitation triage.

42568957

17

🟡 Legacy (Associative)

DNA methylation in bipolar disorder: mechanistic insightsAssociative Epigenetics: Delineates neurotransmitter methylation markers that remain experimental. Findings are associative rather than causal and lack blood-brain barrier delivery validation.

42568843

18

🟡 Legacy (Administrative)

Editorial: Abnormal visual processingInstitutional Filler: General introductory editorial commentary regarding visual stream processing dynamics without any therapeutic interventional data.

42568734

19

🟡 Supportive 🟡 Legacy

Effects of acute and long-term exercise modalities on BDNF in strokeAutomated Target Validation: Bayesian network meta-analysis proving long-term, high-dose multicomponent exercise upregulates peripheral BDNF. Validates BRIGHT’s automated exercise targets.

42568697

20

🟡 Legacy (Clinic Bound)

Imaging Evaluation to Determine Timing of Early Rehab in Pediatric ABIHospital Baseline Constraint: Case report using active practice safely in a 1-year-old boy. Disqualified from home use as it relies on imaging-based diagnostic assessment to time acute mobilization.

42568691

21

🟡 Supportive 🟡 Supportive

Neuroplasticity After Stroke: Implications for RehabilitationCore Software Verification: Reviews robotic-assisted and sensor-based training to leverage Hebbian and homeostatic plasticity. Confirms established therapeutic concepts already built into the engine.

42568667

22

🟡 Supportive (Clinic Bound)

Emergence From MCS Following Addition of Zolpidem to AmantadineComplex Institutional Protocol: Escalates amantadine to 200 mg/day to raise CRS-R scores. Requires centralized hospital PET-CT metabolic brain tracking to verify the active baseline.

42568638

23

🟡 Legacy (Clinic Bound)

Irreversible Brainstem Atrophy After Fibrin-Sealant HypersensitivityInpatient Prognostication: Evaluates delayed immune-mediated ventral medullary injury. Uses prolonged evoked potentials to establish a neuroplastic ceiling, locked to inpatient critical care.

42568611

24

🟡 Legacy (Narrative)

Neuroprotective effects of noble gases following acquired brain injuryPreclinical Narrative: Reviews xenon and argon properties to reduce secondary injury pathways. Notes clinical translation is tightly restricted by gas delivery infrastructure.

42568591

25

🟡 Legacy (Descriptive)

Brain heart crosstalk after ischemic stroke: unified frameworkDescriptive Pathology: Delineates neuroinflammation and catecholamine surges, but notes data remains observational or derived from non-stroke populations.

42568529

26

🟡 Supportive (Animal Only)

Complement C3 inhibitory peptide AMY-101 in NMOSDEarly Biological Phase: Demonstrates reduced astrocyte loss, AQP4 depletion, and demyelination via complement inhibition. Restricted to cell lines and an intracerebral injection mouse model.

42568287

27

🟡 Legacy (Acute Phase)

Neuroprotection and Enhanced Hemoglobin Excretion by ClazosentanHyperacute Window: Investigates a 24-hour continuous intracerebroventricular infusion to limit early subarachnoid neuroinflammation in mice. Out of scope for chronic injury.

42568063

28

🟡 Legacy (Observational)

Implications of Non-Fatal Strangulation-Acquired Brain InjuryObservational Synthesis: Integrative review of cognitive and emotional deficits in IPV survivors, advocating for clinical screening guidelines without active repair mechanisms.

42568014

29

🟡 Supportive (Animal Only)

PDCD1 Signaling in Microglia Can Reduce NeuroinflammationInvasive Rodent Traps: Uses a controlled cortical impact mouse model and knockdown vectors to map microglial inflammation and apoptosis via the PI3K/Akt pathway.

42567990

30

 🟡 Supportive (Animal Only)

 rTMS promotes motor recovery after spinal cord injury in rats ➔ Animal Isolation: High-frequency rTMS drives corticospinal tract projections distal to a lesion via MEK/ERK signaling, but tested strictly in adult female rats.

42567502

31

 🟡 Legacy (Acute Phase)

 Intrahospital Transport-Related Adverse Events in Neurosurgery ➔ Emergency突发 Window: Tracks oxygen saturation drops and vasoactive support complications during acute ICU transfers, providing no chronic neurorehabilitation metrics.

42567224

32

 🟡 Legacy (Observational)

 Emergence and remission of suicidal thoughts and behaviors after TBI ➔ Retrospective Database Profile: Extracts ten-year demographic and psychiatric histories from national model systems, functioning as descriptive data with no active interventional leverage.

42551564

33

 🟡 Legacy (Subjective Metric)

 Validation of QOLIBRI-KIDDY questionnaires after paediatric TBI ➔ Subjective Metric Tool: Statistical validation of self-rated and proxy-rated quality of life questionnaires, serving as an assessment tool with no neuroplastic remodeling capacity.

42566716

34

 🟡 Legacy (Clinic Bound)

 Neuroimaging of the ictal-interictal continuum: systematic review ➔ Heavy Diagnostic Machine: Meta-analysis pooling CT perfusion and PET detection rates for peri-ictal neuroimaging abnormalities, locked within advanced hospital networks.

42566300

35

 🟡 Legacy (Descriptive)

 From Recanalization to Failed Recovery: No Reflow, No Rescue, No Regrow ➔ Descriptive Literature: Proposes a mechanistic framework for futile macrovascular reperfusion due to capillary obstruction, serving as an academic review of known barriers.

42566118

36

 🟡 Legacy (Animal Only)

 Fluoride exposure induces oxidative damage in primary astrocytes ➔ Toxin Biology Trap: Evaluates reactive oxygen species bursts and the Nrf2-NQO1 pathway in primary astrocytes from SD rats under environmental toxin stress.

42566077

37

 🟡 Legacy (Acute Phase)

 Retraction Note: Chrysin attenuates TBI-induced recognition memory decline ➔ Out of Scope: Retraction of a historical study involving antioxidant pathways in acute traumatic rodent models.

42566018

38

 🟡 Legacy (General Advice)

 A peripheral perspective on brain health: vascular and skeletal muscle ➔ General Lifestyle Advice: Review of the muscle-vascular-brain axis, concluding that general resistance training may preserve cognitive health, offering no precise hardware control.

42555788

39

 🟡 Supportive (Clinic Bound)

 Mapping basal ganglia circuitry in altered states of consciousness ➔ Institutional Neuro-Mapping: Connects functional MRI connectivity to propofol anesthesia networks, locked to multi-million dollar clinical fMRI infrastructure.

42555506

40

 🟡 Supportive (Clinic Bound)

 Anatomical and functional state of corticospinal tract in severe TBI ➔ Complex Diagnostic Layout: Compares muscle strength to single-pulse transcranial magnetic stimulation (sTMS) thresholds, locked within institutional emergency pediatric surgery clinics.

42555404

41

 🟡 Legacy (Institutional)

 Mild neonatal hypoxic-ischemic encephalopathy: current controversies ➔ Institutional Discussion: Reviews the uncertainty of therapeutic hypothermia timing and outcome definitions in mild HIE, serving as descriptive clinical policy.

42555342

42

 🟡 Legacy (Acute Phase)

 Late neurologic outcomes in severe anoxic brain injury after arrest ➔ Prognostic Follow-up: Tracks longitudinal 12-month mortality and severe disability (CPC 3-4) following delayed awakening patterns in an acute multicenter cohort.

42555112

43

 🟡 Legacy (Out of Scope)

 Baseline Performance on Concussion Assessments of Athletes Who Are Deaf ➔ Descriptive Profiling: Cross-sectional baseline mapping of Division III athletes using standard tandem gait and neurocognitive testing, identifying adaptations without repair.

42554964

44

 🟡 Legacy (Descriptive)

 Central neuroendocrine dysregulation in ischaemic stroke sequelae ➔ Descriptive Pathology: Narrative review linking chronic HPA axis hyperactivity and glucocorticoid resistance to depression, mapping a known pathway without intervention.

42554771

45

 🟡 Legacy (Descriptive)

 Structural brain injury on MRI in heart failure and high-risk patients ➔ Descriptive Informatics: Uses cluster analysis to associate systemic inflammation and lacunes with age and hypertension, documenting brain abnormalities without treating them.

42554725

46

 🟡 Legacy (Socio-Behavioral)

 Athletic Trainers That Influence Subjectivity in Medical Disqualification ➔ Socio-Behavioral Survey: Online questionnaire evaluating the personal opinions and experience of athletic trainers during concussion discussions, presenting no physiological data.

42554671

47

 🟡 Legacy (Acute Phase)

 Correlation of Contusion Morphology and Volume With Functional Recovery ➔ Surgical Workflow: Prospective tracking of traumatic cerebral contusions on non-contrast CT to predict decompressive craniectomy needs, locked to emergency surgical suites.

42554511

48

 🟡 Legacy (Surgical)

 Continuum of Irreversible Sequelae: Axonal Injury and Hydrocephalus ➔ Surgical Assessment: Reviews ventriculomegaly versus post-traumatic hydrocephalus to select patients for programmable shunts, serving as a standard neurosurgical diagnostic guide.

42554451

49

 🟡 Supportive (Clinic Bound)

 Automated Semisupervised Measurement of ONSD From CT Following TBI ➔ Automated Target Validation: Introduces a deep-learning slice selection pipeline to measure optic nerve sheath diameter automatically. Validates computer-vision tracking metrics but requires clinical CT scanners.

42554439

50

 🟡 Legacy (Acute Phase)

 Surgical Versus Conservative Management in Severe TBI (GCS 3-4) ➔ Surgical Triage: Retrospective tracking of mass lesion evacuations performed within 6 hours of injury, locked completely within specialized critical care operating theaters.

42554423

51

🟡 Legacy Animal Only / Acute

Pediatric Repetitive Mild Traumatic Brain Injury Elicits T Cell-Mediated NeuroinflammationPathology Target: Proves rmTBI triggers CD4+/CD8+ T-cell white matter infiltration in the corpus callosum using TCRβ-/- δ-/- mouse lines.

42564368

52

🟡 Legacy Acute Phase

Predicting Traumatic Brain Injury Outcomes: Clinical Signs, Laboratory Indicators and RadiologyEmergency Triage: Correlates hypernatremia and Marshall grade IV with ICU mortality, establishing acute triage baselines rather than chronic active repair.

42564358

53

🟡 Legacy Administrative

Brain-Dead Organ Donation in Neurosurgical Care: Roles of Neurosurgeons and KODAInstitutional Policy: Outlines the clinical pathway and institutional framework for organ procurement following severe TBI and ischemic/hypoxic brain injury in Korea.

42564300

54

🟡 Legacy Acute Phase

Efficacy of early enteral nutrition in patients with traumatic brain injuryICU Nutrition Timeline: Meta-analysis demonstrating that initiating enteral nutrition within 48 hours of TBI reduces sepsis and mechanical ventilation days.

42564143

55

🟡 Legacy Acute Phase

Traumatic brain injury in patients with mechanical heart valves on lifelong anticoagulationEmergency Hematology: Retrospective analysis of early anticoagulation reversal strategies and admission INR values following acute intracranial hemorrhage.

42564064

56

🟡 Legacy Observational

Early-Life Clinical Factors Shape Cerebellar Structure in Preterm-Born ChildrenDevelopmental Profiling: Correlates mechanical ventilation and opioid exposure in very preterm neonates with reduced cerebellar subregion volumes at age 8.

42563932

57

🟡 Legacy Palliative

Pediatric Neuropalliative Medicine Clinic: Five-Year Data Characterizing a Novel ModelCare Workflow: Tracks consultative outpatient clinics managing complex directives and code status for fragile children with epileptic encephalopathy and ABI.

42563917

58

🟡 Legacy Observational

Region-Specific Brain Imaging Correlates of Repetitive Head Impact ExposureStatic Imaging Profile: Measures postseason frontal cortex mean diffusivity changes correlating with cumulative nonconcussive football impacts.

42563522

59

🟢 Additive Animal Only

Injectable Supramolecular Hydrogel Encapsulating CRISPR-Engineered MSCsActive Catalyst Switch: Modifies molecular microenvironments via self-healing hydrogels delivering gene-edited stem cells to multiplex the activation of repair factors IL-10/FGF21.

42563249

60

🟡 Legacy Observational

Magnetoencephalography and Neuroplasticity: Lifetime Concussions and Head Impact ExposureRetrospective Tracking: Multivariable linear regression matching total years of contact sport exposure to somatic and cognitive scores, finding no exit-level changes.

42563206

61

🟡 Legacy Observational

Phenotype-specific white matter microstructural alterations in Wilson diseaseStatic Pathology Profile: Applies NODDI diffusion imaging to distinguish neurite density reductions in neurological versus hepatic phenotypes, showing no repair.

42562855

62

🟡 Legacy Observational

Vascular risk factors’ impact on motor performance and SMN integrity in MSComorbidity Profile: Uses Expanded Disability Status Scale maps to demonstrate how hypertension and dyslipidemia compound region-specific sensorimotor gray/white matter loss.

42562771

63

🟡 Supportive Clinic Bound

Impact of the hybrid emergency room system on long-term functional outcomesGait Loop Validation: Shows a major reduction in time-to-CT (11 min) and surgery (48 min) via single-suite IR/OR architecture, accelerating known macro-stabilization loops.

42562704

64

🟡 Legacy Observational

Everolimus for the treatment of neuropsychological deficits in TSCPharmacological Tracking: Multi-centre randomized trial tracking memory and executive function changes under mTOR inhibitors, finding small effect sizes and high practice effects.

42562625

65

🟡 Legacy Administrative

Fifteen-minute consultation: The mimics of cerebral palsyDiagnostic Screening Framework: Establishes a clinical paediatric screening framework to differentiate static CP from progressive genetic, metabolic, or neurodegenerative mimics.

42562624

66

🟡 Legacy Observational

Early hand preference and infantile spasms: A case of left-sided cerebral palsyDescriptive Case Profile: Documents early hand dominance as a clinical indicator of focal hemisphere injury and asymmetrical structural integrity.

42562440

67

🟡 Legacy Observational

Factors Associated With Accelerated Fracture Healing in Patients With TBIPhysiological Sarcopenia Profile: Retrospective study correlating younger age and greater TBI severity (low GCS) with neurohumoral-driven accelerated bone regeneration.

42562380

68

🟡 Legacy Animal Only

Creatine preserves mitochondrial integrity via regulation of Na⁺,K⁺-ATPaseMetabolic Baseline Modifier: Demonstrates that oral post-injury creatine preserves mitochondrial respiratory chain complex I-III and CKm activity in fluid-percussion injured rats.

42562329

69

🟡 Legacy Observational

Assessment and Management of Spastic Shoulder in Patients with Brain InjuryManual Workflow: Reviews the integration of motor blocks, botulinum toxin, stretching, and surgical tenotomies to execute personalized, manual SMART clinical goals.

42562179

70

🟢 Additive Animal Only

Mas receptor activation promotes mitophagy and preserves neuronal functionActive Catalyst Switch: Introduces a precise biochemical toggle via the selective agonist AVE0991 to reactivate PINK1/Parkin-mediated mitochondrial clearance loops.

42562073

71

🟡 Supportive Clinic Bound

Effects of BCI-Based Training on Post-Stroke Lower Limb RehabilitationGait Loop Validation: Systematic review confirming BCI closed-loops improve lower limb Fugl-Meyer scores, validating established automated movement loops.

42562060

72

🟡 Legacy Acute Phase

Nationwide Analysis of Hospital Disposition After Tracheal IntubationICU Epidemiology Profile: Weights survey designs across 2 million emergency department encounters to track hospital mortality risk interactions between age and cerebral hemorrhage.

42561872

73

🟡 Legacy Observational

An examination of the association between physical health conditions and suicideRetrospective Database Profile: Uses population-based NESARC-III data to isolate independent risk correlations between lifetime epilepsy diagnoses and psychiatric burden.

42561605

74

🟡 Supportive Clinic Bound

Kinematic-muscular synergies describe biomechanics of locomotion in CPHardware Target Matching: Applies mixed-matrix factorization to 8 lower-limb muscles and joint accelerations, validating tracking targets for automated sensory hardware.

42561535

75

🟡 Legacy Narrative

Neuroimmune mechanisms of the gut-brain axis in treatment-resistant depressionDescriptive Gut-Brain Profile: Reviews microbial SCFA-producing taxa and kynurenine/tryptophan ratios as experimental biomarkers, lacking direct home intervention loops.

42561489

76

🟡 Supportive Home Scalable

Adaptive seating for children with cerebral palsy classified as GMFCS IV-VScalable Delivery Validation: Validates that low-cost, commercially available car seats significantly improve Posture and Posture Ability Scale (PPAS) scores at home.

42561382

77

🟡 Legacy Narrative

Commentary on reflections on participation in the communityInstitutional Filler: Summary commentary discussing subjective, self-reported social participation variables in young people with cerebral palsy.

42561381

78

🟡 Legacy Acute Phase

Surgical stabilization of flail chest: Patient selection and outcomesICU Surgical Profile: Uses ACS-TQIP registry data to track ventilator-free days following SSRF interventions in trauma patients with concomitant severe head injury.

42560998

79

🟡 Supportive Clinic Bound

A trans-therapeutic signature of recovery in internet gaming disorderCore Software Verification: Applies PLS regression and similarity network fusion to RS-fMRI data, mapping cortical-subcortical network rebalancing during active training.

42560759

80

🟡 Supportive Clinic Bound

Effects of a Virtual Reality-Based Balance Training Program on Clinical OutcomesGait Loop Validation: Pairs 4 weeks of VR balance training with resting EEG band tracking to correlate motor coordination gains directly with alpha/beta power increases.

42560357

81

🟡 Legacy Narrative

Motor learning in children with movement difficulties: modified Delphi studySocio-Behavioral Survey: Maps standard Likert-scale consensus among paediatric physiotherapists trying to reconcile traditional impairment normalisation with active motor rules.

42560351

82

🟡 Legacy Observational

Neuropsychiatric Consequences of Subjective Return-to-Activity MeasuresStatic Biomarker Profile: Correlates persistent post-concussion pupillary light reflex (PLR) velocity constriction deficits with depressive and anxious symptom scores.

42560280

83

 🟡 Legacy   Animal Only

 A Hybrid Paradigm to Develop Head Injury Criteria for Behind Helmet Trauma ➔ Preclinical Modeling: Reanalyzes PMHS forces and risk curves to build helmet Deflection Injury Criteria, combining cadaveric and live animal data points.

42560270

84

 🟡 Legacy   Observational

 Provider Perceptions of Current Concussion Care Practices for Service Members ➔ Socio-Behavioral Survey: Focuses on thematic qualitative survey interviews with military primary care providers discussing Progressive Return to Activity tracking friction.

42560204

85

 🟡 Legacy   Observational

 Exploring Relationship Between Hearing Status, Cognitive Function, and Blast Burden ➔ Static Biomarker Profile: Tracks retrospective military registries to correlate service-related blast exposures with somatosensory and vestibular symptom variance.

42560200

86

 🟡 Legacy   Narrative

 A scoping review of therapies to support marriages after acquired brain injury ➔ Socio-Vocational Tracking: Systematic review compiling relationship interventions, family therapy, and emotion-focused trials, noting weak overall designs and low effect sizes.

42560025

87

 🟡 Legacy   Observational

 Three-Year Outcomes Following Hip Reconstruction in Cerebral Palsy ➔ Static Surgery Profile: Utilizes TriNetX federated insurance tracking to document early hardware dislocation and late-stage hardware infection incidence across 1,037 cases.

42559698

88

 🟡 Legacy   Animal Only

 mPFC hemorrhage induces hippocampal CA1 dendritic spine plasticity ➔ Early Pathology Trap: Evaluates attentional shifting set-loss errors alongside hemisphere-specific Golgi staining in a mouse model of intracerebral hemorrhage.

42559649

89

 🟡 Legacy   Acute Phase

 Successful endoscopic evacuation of traumatic intracerebral hemorrhage ➔ Hyperacute Surgery: Reports technical feasibility parameters for rigid neuroendoscopic hematoma purging through focal skull burr holes during acute traumatic decompressive episodes.

42559473

90

 🟡 Legacy   Invasive

 Delayed traumatic spinal epidural hematoma after mild TBI ➔ Surgical Case Profile: Case report detailing a late-presenting T11-L5 stenosis requiring an invasive unilateral laminotomy for bilateral mechanical decompression.

42559466

91

 🟡 Legacy   Administrative

 Economic burden and cost drivers of traumatic brain injury ➔ Socio-Economic Tracking: Cross-sectional cost analysis measuring Togolese direct medical out-of-pocket expenditures against the national monthly minimum wage baseline.

42559368

92

 🟡 Legacy   Observational

 Head Impact Exposure Across Levels of Play in American Football ➔ Static Biomarker Profile: Accelerometer-based systematic review matching youth and collegiate linear/rotational impact frequencies without exposure denominators.

42559270

93

 🟡 Legacy   Acute Phase

 Transient Bilateral Fixed Dilated Pupils Following Papaverine Use During MVD ➔ Emergency Pharmacology: Case report analyzing transient intraoperative mydriasis mimicking catastrophic brainstem herniation due to local papaverine infiltration.

42559265

94

 🟡 Legacy   Observational

 Genetic factors complicating recovery in brain injury: Intracerebral amyloid ➔ Static Genetic Profile: Narrative review evaluating the associations of apolipoprotein E epsilon 4 (APOEε4) variants with secondary Aβ deposition and lobar hemorrhage risk.

42559224

95

 🟡 Legacy   Observational

 Decoding everyday levels of musical training from subcortical white-matter ➔ Static Brain Profile: Applies cross-validated machine learning on diffusion MRI structural connectomes to weigh fiber bundle capacity against self-reported skill sets.

42559177

96

 🟡 Legacy   Observational

 The Response of the Default Mode Network to Aerobic Exercise in Concussion ➔ Static Brain Profile: Graph theory analysis tracking network efficiency and right lateral parietal node connectedness changes following submaximal treadmill trials in youth.

42558972

97

 🟡 Legacy   Narrative

 Lacosamide Use After Traumatic Brain Injury: A Scoping Review ➔ Preclinical Narrative: Charts 10 heterogeneous clinical and rodent trials assessing LCM sodium-channel slow inactivation for early post-traumatic seizure prophylaxis.

42558887

98

 🟡 Legacy   Administrative

 A Multiliteracies Approach to Transforming Written Cases Into Video Cases ➔ Educational Design: Iterative design thinking project developing contextually grounded video simulation models for speech pathology and clinical reasoning training.

42558789

99

 🟡 Legacy   Palliative

 Growth Modulation of Proximal Femur Physis in CP and DDH ➔ Static Surgery Profile: Meta-analysis comparing radiographic neck-shaft angles and reoperation metrics in children undergoing temporary medial hemiepiphysiodesis screws.

42558785

100

 🟡 Legacy   Low Impact

 Efficacy and Safety of Hopantenic Acid in Pediatric NDDs ➔ Active Catalyst Switch: Systematic review evaluating an oral GABA-B agonist to modulate psychomotor stability, passing home delivery metrics but carrying an unmodifiable liver metabolism barrier.

42558633

101

🟡 Legacy Observational

Comorbidities in children with cerebral palsy: retrospective observational study in UAEDevelopmental Profiling: Explores comorbidity burden across CP subtypes, highlighting global developmental delay (78.6%) and drug-resistant epilepsy (63.7%). Documents static state variations without active neuro-repair pathways.

42558534

102

🟡 Legacy Narrative

Oxidative stress as a driver of organelle cascade damage in neurological diseasesDescriptive Pathology: Outlines inter-organelle crosstalk and cascade damage under cellular stress, mapping a known degenerative cascade without an adaptive home intervention engine.

42558527

103

🟡 Legacy Narrative

Exercise as an adjunct intervention for social anxiety disorder: a mini-reviewGeneral Advice: Synthesizes the general benefits of aerobic activity on mental resilience and body image, offering subclinical behavioral guidance without precise hardware loop integration.

42558442

104

🟡 Legacy Acute Phase

Colchicine for the Prevention of Vascular Events After an Acute Intracerebral HemorrhageHyperacute Pilot: Evaluates short-term safety and recruitment feasibility of low-dose colchicine started within 48 hours of an acute stroke, finding no early efficacy signals.

42558067

105

🟢 Additive Animal Only

Gas-6 Scavenges Anionic Phospholipid-Expressing Microparticles and Mitigates TBI PathologyActive Catalyst Switch: Employs exogenous Gas-6 to actively purge thromboinflammatory debris and protect endothelial tight junctions. Disqualified from home translation due to early preclinical mouse restraints.

42558045

106

🟡 Legacy Animal Only

Multipathway modulation of neuroinflammation and oxidative stress by hesperidinLow Impact Trap: Citrus supplement alters cytokine balances in a preclinical rat model, but faces a brutal >95% first-pass liver metabolism barrier that strips its real-world clinical potency.

42557968

107

🟡 Supportive Home Scalable

Comparison of Synchronous Telerehabilitation and Face-to-Face Methods in Hemiparetic CPScalable Delivery Validation: Confirms that home telerehabilitation delivery of activity-based training yields equivalent functional motor improvements (QUEST/SHUEE) as on-site clinical camps.

42557830

108

🟡 Legacy Narrative

Sport-Related Concussion Prevention Programs in Soccer: A RE-AIM Scoping ReviewAdministrative Informatics: Maps soccer-based concussion awareness and neck-strengthening educational programs, finding a complete absence of long-term tracking data.

42557515

109

🟡 Legacy Administrative

Trends and disparities in gun violence-related neurotrauma incidence across the USSocio-Economic Tracking: Uses the Global Burden of Disease registry to quantify three-decade socioeconomic and regional variations in firearm-related TBI and SCI disability markers.

42557490

110

🟢 Additive Animal Only

Hematopoietic Growth Factors Induce More Extensive Transcriptomic Remodeling in Chronic TBIActive Catalyst Switch: Drives active microenvironmental repair by delivering subcutaneous SCF + G-CSF to induce anti-inflammatory transcriptomic phenotypes in cerebral monocytes. Restricted to mice.

42557436

111

🟡 Legacy Acute Phase

Albumin-Anchored Thromboinflammatory Ratios Provide Modest Prognostic Value in aSAHEmergency Biomarker Profile: Analyzes acute D-dimer-to-albumin ratios within 24 hours of hemorrhage to predict in-hospital mortality and early structural failure.

42557435

112

🟡 Legacy Acute Phase

The Effects of Transport Altitude on Outcomes in Traumatic Brain Injury (HEIGHT-TBI)Emergency Workflow: Observational tracking linking hypobaric aeromedical flights above 6000 ft and in-flight hypotension to increased acute mortality trends in acute trauma cohorts.

42557135

113

🟡 Supportive Clinic Bound

Clinical outcomes of transposition osteotomy of the acetabulum for neurogenic hip dysplasiaSurgical Optimization: Restores joint coverage and provides mid-term pain relief via major joint reconstruction surgery, tracking structural mechanical correction loops.

42556987

114

🟡 Legacy Narrative

Drugs and Cell-Based Therapies for the Prevention and Treatment of Neonatal Brain InjuryInstitutional Discussion: Summarizes the uniform failure of clinical erythropoietin trials for neonatal brain injury, documenting institutional evidence blocks rather than active repair.

42556981

115

🟡 Legacy Institutional

Proven Neonatal Neuroprotection Strategies: Magnesium Sulfate and Therapeutic HypothermiaHyperacute Institutional: Outlines established obstetric and NICU guidelines for magnesium delivery and cooling protocols to mitigate hyperacute HIE cascades.

42556773

116

🟡 Legacy Animal Only

C1q dependency of retinal ganglion cell death in blast-mediated traumatic brain injuryStatic Pathology Profile: Evaluates long-term optic nerve axonal survival using C1qa genetic knockout mouse strains exposed to blast-mediated secondary degeneration.

42556720

117

🟡 Legacy Invasive

Modified Expansion-Floating Craniotomy for Refractory Intracranial HypertensionSurgical Profile: Evaluates a bone-flap-preserving bedside Quick-Release repositioning knot to relieve malignant pressure, requiring an invasive acute skull opening.

42556656

118

🟡 Legacy Narrative

The role of PANoptosis regulatory networks in acute neurological injuryDescriptive Pathology: Synthesizes molecular cell-death pathways (ZBP1/RIPK1) in early stroke and spinal models, organizing structural definitions without dynamic hardware interventions.

42556602

119

🟡 Legacy Observational

Altered Mechanical Somatosensory Processing in Young People with Cerebral PalsyStatic Biomarker Profile: Applies age-referenced z-score sensory testing to map elevated mechanical pain thresholds, showing a disconnect between neural thresholds and subjective distress.

42556487

120

🟢 Additive Animal Only

Microglial SREBP2 Regulate Cholesterol Metabolism and Inflammation Post-StrokeActive Catalyst Switch: Manipulates the microglial SREBP2 autophagy pathway to resolve toxic cholesterol accumulation and improve survival rates in MCAO models. Restricted to mice.

42556280

121

🟡 Supportive Clinic Bound

Propranolol attenuates systemic inflammatory response in aged TBI patientsSurgical Optimization: Retrospective cohort and rodent study utilizing beta-blockade to shift peripheral bone marrow monocyte infiltration, modifying systemic trauma pathways.

42556181

122

🟡 Supportive Clinic Bound

Effect of extracorporeal shock wave therapy on gastrocnemius spasticity in CPHardware Target Matching: Pairs 12 weeks of high-powered, clinic-bound ESWT with sonographic monitoring to achieve short-term GMFM score improvements, validating localized muscle targets.

42556048

123

🟡 Legacy Subjective Metric

Comparing PROMIS Global Health and Rivermead Post-concussion Symptoms QuestionnaireSubjective Metric Tool: Statistical validation study showing poor individual patient-level agreement between global health surveys and symptom-specific TBI metrics.

42556001

124

🟡 Legacy Acute Phase

Association of time-averaged systemic immune-inflammation indices with mortality after ICHICU Epidemiology Profile: Extracts MIMIC-IV database metrics over 72 hours post-stroke to map non-linear mortality spikes linked to early systemic inflammatory acceleration.

42555976

125

🟡 Legacy Animal Only

Esketamine alleviates neuroinflammation and cognitive impairment in male 3xTg-AD micePreclinical Modeling: Links esketamine protection to the TAOK1/IL-17 axis, but executed strictly in a transgenic rodent model with an unverified chronic human transfer horizon.

42555907

126

🟡 Legacy Observational

Distinct Patterns of Syntactic Errors Doubly Dissociate in Chronic Poststroke AphasiaStatic Brain Profile: Conducts voxelwise lesion-symptom mapping to connect expressive linearization errors to frontal cortex lesions, detailing speech damage without treatment.

42555850

127

🟡 Legacy Animal Only

Endothelin-1 Signaling Mediates Hypoxia-Induced Microglial ActivationEarly Pathology Trap: Evaluates the endothelin B receptor antagonist BQ788 to limit hypoxia-induced interleukin-6 surges in human HMC3 cell cultures, missing systemic integration.

42555794

128

🟢 Additive Animal Only

A Supramolecular Nanoagent Modulates PINK1/Parkin-Associated Mitophagy SignalingActive Catalyst Switch: Engineers a PC-based supramolecular self-assembly nanoagent to cross the BBB and reactivate PINK1/Parkin mitophagy loops in tMCAO models. Restricted to animals.

42555369

129

🟡 Legacy Acute Phase

Extensive Biventricular Subendocardial Infarction as Secondary Brain HitEmergency Care Window: Postmortem case study delineating extensive cardiovascular shock and myocardial collapse accelerating early infant brain death during hyperacute asphyxia.

42555051

130

🟡 Legacy Socio-Vocational

Relative importance of work-related factors on return to work in adults with PPCSVocational Tracking: Longitudinal dominance survey correlating structural workplace pacing and long-term home-office plans with overall employment outcomes post-concussion.

42554671

131

 🟡 Legacy   Animal Only

 Role of β-Arrestin2 Signaling in Neuropharmacological Effects of Psychedelic Drugs ➔ Preclinical Modeling: Uses β-arrestin2 knockout mouse models to prove that psilocin-evoked dendritogenesis depends on separate pathways from standard hallucinogenic head-twitches.

42554560

132

 🟡 Legacy   Narrative

 Social Isolation and Loneliness After Brain Injury: What Can Be Done? ➔ Institutional Filler: Consumer-facing outpatient checklist brochure providing general advice to self-manage isolation and loneliness following an acquired brain injury.

42554325

133

 🟡 Legacy   Genetic Profile

 Case report: Adult presentation of glutaric aciduria type I ➔ Static Case Profile: Documents a 53-year-old bedridden patient historically misdiagnosed with static cerebral palsy who carries a progressive, homozygous genetic metabolic mutation.

42554164

134

 🟡 Legacy   Narrative

 Glymphatic-meningeal lymphatic dysfunction drives remote organ injury after aSAH ➔ Descriptive Pathology: Proposes a theoretical framework linking intracranial fluid drainage failures to systemic humoral signal propagation, outlining a known systemic path.

42554104

135

 🟡 Legacy   Observational

 Characterizing the Prevalence of Dementia Risk Factors in Moderate-to-Severe TBI ➔ Static Biomarker Profile: Retrospectively matches 106 chronic TBI survivors with healthy controls to isolate long-term risk profiles across smoking, sleep, and auditory domains.

42554099

136

 🟡 Legacy   Narrative

 Letter: Recovery from Traumatic Brain Injury Takes Months; Our Care Systems Last Weeks ➔ Institutional Filler: Academic opinion letter discussing the administrative timeline disparities between clinical medical insurance constraints and chronic recovery trajectories.

42553827

137

 🟡 Legacy   Acute Phase

 Transcranial Doppler pulsatility index for predicting neurological deterioration in TBI ➔ ICU Triage: Prospective monitoring of middle cerebral artery velocities to establish a bedside PI threshold of ≥1.25 for identifying secondary mechanical failures within 7 days.

42553698

138

 🟡 Legacy   Observational

 Concussion is associated with multiple sclerosis if it occurs before IM ➔ Static Genetic Profile: Uses Swedish national health registries to track statistical risk interactions between adolescent concussions and late Epstein-Barr virus/IM primary infections.

42553473

139

 🟡 Legacy   Administrative

 Predicting Outcomes of TBI Using Machine Learning Models at KCMC, Tanzania ➔ Administrative Informatics: Develops Random Forest and Decision Tree predictive algorithms to categorize 12-month Glasgow Outcome Scale risks using standard trauma registry variables.

42553406

140

 🟡 Legacy   Animal Only

 Soluble Glycoprotein 130 Improves Cognitive Outcomes Following CCI in Mice ➔ Preclinical Modeling: Demonstrates that a single intrahippocampal or systemic dose of sgp130Fc inhibits pro-inflammatory interleukin-6 trans-signaling in controlled cortical impact models.

42553321

141

 🟡 Supportive   Home Scalable

 Effect of Parent-Mediated Home-Based Rehabilitation Program in Children With CP ➔ Scalable Delivery Validation: Quantifies highly significant improvements across COPM, WeeFIM, and GMFM-66 scales using a structured 10-week low-cost caregiver training framework.

42553277

142

 🟡 Supportive   Clinic Bound

 Lower extremity exoskeleton robot on the improvement of walking ability in SCI ➔ Hardware Target Matching: Meta-analysis pooling 10 powered lower-limb exoskeleton trials to confirm improvements in 6MWD and WISCI-II scores, matching automated locomotion profiles.

42553245

143

 🟡 Legacy   Subjective Metric

 Brief checklist of modifiable dementia risk factors (RF12) in an Italian cohort ➔ Subjective Metric Tool: Cross-sectional study evaluating the statistical variance in standard cognitive scores (MMSE/MoCA) explained by a self-reported 12-item lifestyle questionnaire.

42553203

144

 🟡 Supportive   Clinic Bound

 Real-time approach to evaluate spinal cord topography of motor pool activation ➔ Hardware Target Matching: Reverse-projects lower-limb surface EMG activity to visualize dynamic 3D lumbo-sacral heat maps during clinical gait analysis. Redundant against 0.1mm-resolution arrays.

42553201

145

 🟡 Legacy   Animal Only

 Persistent hypersensitivity after repeat concussion is associated with cognitive deficits ➔ Early Pathology Trap: Evaluates tactile sensitivity and cognitive flexibility using repeat closed-head impact models in 4-month-old mice under complex sensory loads.

42553153

146

 🟡 Legacy   Acute Phase

 Associations between arterial oxygenation and oxidative stress markers in severe brain injury ➔ ICU Triage: Tracks serum and bronchoalveolar fluid redox parameters across 7 days in mechanically ventilated trauma patients to map oxygenation-driven tissue toxicity thresholds.

42552917

147

 🟡 Legacy   Gut Microbiome

 Short-chain fatty acid-producing psychobiotics in mood disorders ➔ Descriptive Gut-Brain Profile: Narrative review outlining microbiota-derived epigenetic regulation and SCFA-HDAC inhibition pathways, noting human trials remain preliminary and constrained.

42552585

148

 🟡 Legacy   Observational

 Postural Control in Children with Diplegic CP: Association with Cervical Joint Position Sense ➔ Developmental Profiling: Correlates absolute cervical joint position error angles with Trunk Control Measurement Scale (TCMS) dynamic sitting metrics in children aged 5–12.

42552491

149

 🟡 Legacy   Acute Phase

 Early vs. late computed tomography angiography in blunt cerebrovascular injuries ➔ Emergency Triage: Multivariable regression using national trauma quality registries to weigh early CTA stroke risk reduction against injury grade and concussion complications.

42552489

150

 🟡 Legacy   Animal Only

 p-Coumaric Acid Attenuates Lead Acetate-induced Neurotoxicity in Rats ➔ Toxin Biology Trap: Measures dose-dependent qPCR apoptotic shifts (Bax/Bcl-2) and western blot tissue recovery following oral antioxidant administration in lead-poisoned rats.

42552236

151

🟡 Legacy Administrative

Reducing Re-admission Risk After Traumatic Brain InjuryAdministrative Informatics: Restrospective chart audit assessing risk variables and outpatient phone check timelines during the early post-discharge interval to optimize workflow management.

42552236

152

🟡 Legacy Acute Phase

Neuromonitoring: an overviewICU Triage: Narrative summary of invasive clinical monitoring arrays (microdialysis, catheter-based ICP) for acute sedation titration, presenting no chronic active repair strategies.

42552015

153

🟡 Legacy Observational

Perioperative Mammillary Body Injury on MRI in Neonates with CCHDStatic Imaging Profile: Uses retrospective pediatric MRI datasets to correlate low cardiac output syndrome with microstructural mammillary tissue signal loss post-surgery.

42551788

154

🟡 Legacy Administrative

Gaps in Intracranial Pressure Monitoring for Traumatic Brain Injury in ChinaSocio-Economic Tracking: Cross-sectional web survey evaluating regional DRG financial constraints, infection anxiety, and a baseline lack of structured probe insertion training.

42551754

155

🟡 Legacy Descriptive

Electrocardiographic abnormalities secondary to acute central nervous system injuryDescriptive Pathology: Narrative overview mapping central autonomic network breakdown and sympathetic hyperactivation gradients across insular and brainstem strokes.

42551499

156

🟡 Legacy Animal Only

Sex-Based Differences in Severe Trauma and Hemorrhagic ShockPreclinical Narrative: Systematically reviews rodent models manipulating proestrus estrogen levels to track systemic immune-vascular resilience, noting high trial reporting gaps.

42551445

157

🟡 Legacy Animal Only

STING inhibition alleviates post-cardiac arrest brain injuryEarly Biological Phase: Employs the small-molecule inhibitor H151 to drive an M1-to-M2 microglial shift and decrease apoptosis in hyperkalemic cardiac arrest mouse models.

42551197

158

🟡 Supportive Clinic Bound

Cost-effectiveness analysis of HABIT-ILE in preschool children with bilateral CPGait Loop Validation: Multicenter RCT tracking micro-costing ratios per GMFM-66 point gain under high-dose, clinical on-site bimanual skill camps, reinforcing known delivery targets.

42551100

159

🟡 Legacy Acute Phase

Retraction: Tert-Butylhydroquinone Alleviates Early Brain InjuryOut of Scope: Retraction notification for an early-stage academic paper analyzing Nrf2/ARE pathways in acute traumatic subarachnoid hemorrhage.

42550802

160

🟡 Legacy Acute Phase

Oxygen Saturation Thresholds for Opioid-induced Respiratory DepressionEmergency Workflow: Systematic review charting pulse oximetry saturation metrics (85–95% baseline) as an early proxy marker to trigger clinical rescue interventions in toxicity crises.

42550704

161

🟡 Legacy Out of Scope

Point-of-Care EEG for Mild Traumatic Brain Injury TriageEmergency Triage: Evaluates qEEG Brain Function Index scores to route mild concussion patients into military MTF follow-up loops, offering no dynamic chronic structural remodeling.

42550737

162

🟡 Legacy Narrative

Developing a neuropsychiatry curriculum for clinical psychologistsEducational Design: e-Delphi framework mapping core syllabus competencies (autoimmune encephalitis, post-stroke delirium) for post-graduate training, presenting no physiological data.

42550473

163

🟡 Legacy Observational

Long-term prediction of epilepsy following TBI among veteransRetrospective Database Profile: Uses administrative Department of War tracking data to construct a SHAP random forest model mapping pre-injury comorbidity indices onto posttraumatic seizure risks.

42550472

164

🟡 Legacy Animal Only

Caspase-1-mediated pyroptosis drives secondary thalamic neurodegenerationEarly Biological Phase: Targets delayed remote circuit damage via shRNA-mediated caspase-1 knockdown in the thalamus of cortical-ischemia mouse models.

42550293

165

🟡 Legacy Out of Scope

Hippocampal Subfield Volumetry and Navigation in Congenital BlindnessStatic Brain Profile: Maps Cornu Ammonis cytoarchitectonic volume variations matching tactileSubstitution device learning curves in congenitally blind adults.

42549635

166

🟡 Legacy Observational

Mixed-Nerve Silent Period Characteristics During Muscle Output RegulationStatic Biomarker Profile: Uses electrical nerve stimuli to measure knee extensor isometric silent periods, comparing normal athletes to a single post-surgical patient.

42549197

167

🟡 Legacy Low Impact

Sustained abstinence in severe ketamine use disorder following ibogaineAddiction Profile: Case report tracking single-dose ibogaine polypharmacology (kappa agonism, SERT inhibition) to mitigate compulsive reward pathways, lacking scaled chronic neurorehabilitation.

42548882

168

🟡 Legacy Narrative

Dapagliflozin and cognitive impairment: pharmacological mechanismsPreclinical Narrative: Summarizes diabetes metabolic-neurovascular pathways (AMPK-mTOR) in animal lines, concluding human clinical trials fail to verify a definitive cognitive benefit.

42548880

169

🟡 Legacy Observational

Temporalis muscle thickness as a biomarker of functional level in adults with CPStatic Imaging Profile: Uses routine retrospective brain MRI scans to measure temporalis thickness as a surrogate marker for sarcopenia and global muscle mass.

42548303

170

🟡 Legacy Animal Only

Pelargonium Graveolens Essential Oil Improves Recovery after TBILow Impact Trap: Demonstrates steam-distilled geranium oil reduces corpus callosum atrophy and upregulates p-CREB in a weight-drop mouse model, carrying immense absorption blocks.

42547960

171

🟡 Legacy Narrative

Microglial maturation human and mouse as reference for large-animal modelsDescriptive Pathology: Reanalyzes sheep and pig perinatal datasets to match single-cell microglial phenotypes to late-gestation human brain injury windows.

42547841

172

🟡 Legacy Administrative

Impact of Initial Care Facility on Mortality in Moderate-to-Severe TBISocio-Economic Tracking: Employs inverse probability weighting across South African emergency data to match rapid head CT access to institutional surgical survival trends.

42547675

173

🟡 Legacy Narrative

Waveform-Derived Metrics of Intracranial Compliance: ValidationInstitutional Neuro-Mapping: Cross-references pulse shape indices with P2/P1 pulse morphology profiles across 4,388 data segments to automate laboratory diagnostic assessments.

42547674

174

🟡 Legacy Acute Phase

Surgical Versus Medical Management in Older Adults with TBISurgical Triage: Meta-analysis pooling 16 retrospective cohorts to match operative decompression with a reduction in 6-month mortality, showing a complete dissociation from functional recovery.

42547673

175

🟡 Legacy Narrative

Let us stop admiring the problem: we need social prescribing nowInstitutional Filler: Opinion piece advocating for the administrative integration of community recreation vouchers into pediatric disability services, presenting no raw biological tracking.

42547454

176

🟡 Legacy Narrative

Capacity Building Through Psychedelic-Assisted Therapy: SDOHSocio-Behavioral Survey: Conceptual critique arguing against neurobiological reductionism in PAT, advocating for holistic capability tracking frameworks over neuro-centric targets.

42547119

177

🟡 Legacy Animal Only

CKLF1 upregulation exacerbates secondary brain injury after ICHEarly Biological Phase: Targets hemin-induced neuronal ferroptosis via a CCR5/p38/p53 signaling peptide array in differentiated PC12 cells and acute hemorrhagic rat models.

42546807

178

🟡 Legacy Acute Phase

Early versus Late Pharmacologic Thromboprophylaxis in TBIICU Hematology: Propensity-score matched trial evaluating heparin initiation within 72 hours of trauma to balance vascular occlusive events against early hematoma expansion risks.

42546743

179

🟡 Legacy Narrative

Neuroimaging biomarkers of non-invasive brain stimulation: EEG/fMRIPreclinical Narrative: Synthesizes transient connectivity modulations and TMS-evoked potentials, noting high inter-individual outcome variance and a lack of validated active home targets.

42546603

180

🟡 Supportive Clinic Bound

Effectiveness of robotic gait training combined with physiotherapy in CPGait Loop Validation: Retrospective audit of 114 cases comparing high-dose Lokomat sessions (4-5/week) to moderate protocols, validating standard spatial joint-angle targets.

42546483

181

🟡 Legacy Acute Phase

Glucagon-like Peptide-1 levels are associated with feeding intolerance in TBIICU Nutrition Profile: Tracks plasma GLP-1 resistance trajectories in a tertiary neuro-ICU to predict post-trauma gastroparesis and early systemic metabolic failure.

42546448

182

🟡 Legacy Palliative

Palliative hip surgery in nonambulatory children with cerebral palsyStatic Surgery Profile: Compares Egermann versus Girdlestone proximal femoral resections in GMFCS V cohorts to track caregiver-reported pain comfort outcomes.

42546262

183

🟡 Legacy Animal Only

Senescence Associated With Neurodegeneration: simultaneous assessmentPreclinical Modeling: Introduces an academic laboratory protocol combining SA-β-gal activity with Nissl staining to map senescent cell accumulation markers in post-ischemic rodent tissue sections.

42545971

184

 🟡 Legacy   Acute Phase

 Diagnostic accuracy of blood biomarkers for excluding head CT abnormalities ➔ Emergency Triage: DTA meta-analysis evaluating automated GFAP and UCH-L1 assays within 24 hours of trauma to bypass routine head CT runs in mild concussion.

42545797

185

 🟡 Legacy   Subjective Metric

 MRI-based cortical morphometry in traumatic brain injury: pilot study ➔ Subjective Metric Tool: Applies the “recon-all-clinical” segmentation pipeline to axial MRI scans, noting high structural error profiles and segmentation artifact distortion in the presence of focal lesions.

42545489

186

 🟡 Legacy   Acute Phase

 Diagnostic algorithm for the management of patients ≥ 65 years with a mild TBI ➔ Emergency Triage: Employs vote-counting synthesis across German emergency rooms to construct a clinical CT imaging checklist based on 6 initial trauma risk factors.

42545486

187

 🟡 Legacy   Observational

 Multidomain mobility and cognition across lifespan: Stride velocity ➔ Static Biomarker Profile: Accelerometer-based tracking mapping stride velocity and cadence variance onto a derived composite measure of Wechsler executive function in older adults.

42545357

188

 🟡 Legacy   Animal Only

 Lithium carbonate attenuates behavioral alterations in isolated rats ➔ Preclinical Modeling: Demonstrates daily lithium injections partially restore prefrontal BDNF mRNA transcription following chronic isolation stress in male Wistar rats.

42545137

189

 🟡 Legacy   Associative

 Latent Toxoplasma infection mimics the immune profile of schizophrenia ➔ Static Biomarker Profile: Quantifies multiplexed cytokine and KLK6/S100B serum variance in chronically infected cohorts to map associative neuro-immune profiles.

42544925

190

 🟡 Legacy   Narrative

 Neurobiological rationale for using SSRIs and SNRIs in IBD and DGBI ➔ Descriptive Gut-Brain Profile: Synthesizes enteric SERT/NET binding mechanics and vagal anti-inflammatory tone models, noting a complete lack of high-fidelity human interventional data.

42544625

191

 🟡 Legacy   Animal Only

 Fear extinction classic psychedelics MDMA ketamine rodent models ➔ Preclinical Modeling: Regression synthesis pooling 177 allometrically scaled psilocybin and ketamine dosing runs to track threat-extinction recall kinetics in conditioned rodents.

42544550

192

 🟡 Supportive   Home Scalable

 Effect of Combined Pulley and Vibration Therapy on Genu Recurvatum in CP ➔ Scalable Delivery Validation: Quasi-experimental case series demonstrating that home-based task strengthening paired with localized muscle vibration improves mechanical knee hyporextension angles.

42544146

193

 🟡 Legacy   Acute Phase

 Correction: Multidisciplinary Perioperative Care of Infant Severe TBI ➔ Out of Scope: Erratum update regarding acute surgical fluid management guidelines during infant emergency decompressive craniectomy.

42543730

194

 🟡 Legacy   Acute Phase

 Protocol-driven care with complication rates in severe traumatic brain injury ➔ Emergency Triage: Quasi-experimental study tracking systemic ICU fever and decubitus ulcer drop rates following implementation of Brain Trauma Foundation checklists.

42543483

195

 🟡 Legacy   Animal Only

 Pressure-dependent effects of hyperbaric oxygen on healthy rats ➔ Low Impact Trap: Tracks hippocampal GAD67 shifts and object recognition scores following 14 days of HBOT, but executed entirely in an uninjured rodent model with zero active repair capacity.

42543112

196

 🟡 Legacy   Subjective Metric

 Sleep MAPP: decision support tool in polytrauma/TBI system of care ➔ Subjective Metric Tool: Iterative UX prototype software compiling clinician semi-structured interview text and checklist compliance scores to track administrative sleep guidelines.

42543004

197

 🟡 Legacy   Animal Only

 Noninvasive Urinary Biomarkers for Early Diagnosis of Mild TBI ➔ Static Biomarker Profile: Employs headspace GC-MS to isolate volatile urinary ketones in fluid-percussion injured mice, checking bio-banked youth urine samples secondarily.

42542820

198

 🟡 Legacy   Narrative

 Cerebral palsy in a Sudanese tertiary setting: robust framework ➔ Institutional Filler: Summary academic letter arguing over regional data selection parameters and descriptive pediatric case classification frameworks in North Africa.

42542724

199

 🟡 Legacy   Genetic Profile

 Assessment of risk factors for cerebral palsy should include genetic testing ➔ Static Case Profile: Commentary piece detailing historical consanguinity risk multipliers and advocating for mandatory exome taxonomy, lacking an active physiological intervention.

42542686

200

 🟡 Legacy   Observational

 Offline and online de novo motor skill learning in young children ➔ Developmental Profiling: Uses a mirror reversal task to track rule learning (initial direction error) over 7 days, mapping baseline child-versus-adult neurodevelopmental trajectories.

42501448

Citation Details for August 10th, 2026

No.

PMID

Title

1

42571587

Investigation of brain connectivity alteration in the non-severe traumatic brain injury: an emotional condition study.

2

42571483

Observable signs of concussion in professional slap fighting using established video review protocols for professional sports: frequency, predictors, and implications for public concussion recognition awareness.

3

42571358

Whole genome sequencing in cerebral palsy: a UK paediatric pilot study.

4

42571114

Visual Snow Syndrome: Seeing Snowflakes, a Unique Visual Phenomenon Following Mild Traumatic Brain Injury.

5

42570928

Cerebral High-Frame-Rate Ultrasound Imaging and Its Possibilities in the Neonatal Intensive Care Unit.

6

42570370

Posttraumatic epilepsy: Pathophysiology, clinical characteristics and disease within lifespan.

7

42570256

A case study reviewing the critical role of meaningful employment in brain injury rehabilitation: An occupational therapy perspective.

8

42570240

IL-19(+) monocytes suppress neuroinflammation and promote neurological recovery in young individuals with traumatic brain injury.

9

42570207

Altered hippocampal lipid profile underlies anxiety-like behavior secondary to mild traumatic brain injury.

10

42570137

Pulsed Radiofrequency for Post-Stroke Complications: From Neuromodulation to Functional Recovery.

11

42570001

Erratum to: Wu M, Cheng J, Hu Y, Xie J, Huang J, Jiang J, Chen S, Zhang Z, Chen S, Li H, Ko H, Li Y, Tang Y, Xu Y, Lin WJ. Sustained neuronal DNA damage and poly(ADP-ribose) polymerase activation lead to vascular endothelial growth factor A-mediated blood-brain barrier disruption in radiation-induced brain injury. Int J Radiat Oncol Biol Phys 2025;123:1368-1382.

12

42569911

The Open Data Commons for Traumatic Brain Injury: An Interagency Community Platform for Pre-Clinical Data Management and Sharing.

13

42569845

Functional outcomes and barriers of assistive devices for children with cerebral palsy: a cross-sectional study in Rwandan rehabilitation contexts.

14

42569436

Temporal trends in post-cardiac arrest brain injury research: a bibliometric analysis of evolving priorities and translation gaps.

15

42569353

Nanozyme-based therapeutic strategies for traumatic brain injury.

16

42568957

What about guidelines for out-of-hospital cardiac arrest with unusual cardiac anatomy?

17

42568843

DNA methylation in bipolar disorder: mechanistic insights and translational challenges.

18

42568734

Editorial: Abnormal visual processing.

19

42568697

Effects of acute and long-term exercise modalities and doses on brain-derived neurotrophic factor in patients with stroke: a Bayesian network meta-analysis.

20

42568691

Imaging Evaluation to Determine the Timing of Early Rehabilitation in Pediatric Non-Traumatic Acquired Brain Injury: A Case Report.

21

42568667

Neuroplasticity After Stroke: Clinical Evidence and Its Implication for Effective Rehabilitation Strategies.

22

42568638

Emergence From Minimally Conscious State Following Addition of Zolpidem to Amantadine Therapy in a Patient With Preserved Cortical Metabolism After Subarachnoid Hemorrhage: A Case Report.

23

42568611

Irreversible Brainstem Atrophy After Fibrin-Sealant Hypersensitivity: A Neurorehabilitation Perspective: A Case Report.

24

42568591

Neuroprotective effects of noble gases following acquired brain injury: a narrative review.

25

42568529

Brain heart crosstalk after ischemic stroke toward a unified framework for pathophysiology and precision medicine.

26

42568287

Complement C3 inhibitory peptide AMY-101 ameliorates brain injury in a mouse model of NMOSD.

27

42568063

Neuroprotection and Enhanced Hemoglobin Excretion by Intrathecal Clazosentan in Mice With Subarachnoid Hemorrhage.

28

42568014

Silent Trauma: Implications of Non-Fatal Strangulation-Acquired Brain Injury – An Integrative Review.

29

42567990

PDCD1 Signaling in Microglia Can Reduce Neuroinflammation and Apoptosis Induced by Traumatic Brain Injury by Regulating PI3K/Akt Signaling Pathway, Thereby Alleviating Neurological Dysfunction.

30

42567502

High-frequency repetitive transcranial magnetic stimulation promotes motor recovery after spinal cord injury associated with spinal-cortical plasticity.

31

42567224

Incidence and Risk Factors of Intrahospital Transport-Related Adverse Events in Critically Ill Neurosurgical Patients: A Single Institutional Experience from China.

32

42551564

Rates and predictors of the emergence and remission of suicidal thoughts and behaviors after traumatic brain injury: a Traumatic Brain Injury Model Systems National Database study.

33

42566716

Validation of the QOLIBRI-KIDDY self-rated and proxy-rated questionnaires after paediatric traumatic brain injury.

34

42566300

Neuroimaging of the ictal-interictal continuum: Where do we stand? A systematic review and meta-analysis of current evidence.

35

42566118

From Recanalization to Failed Recovery: No Reflow, No Rescue, and No Regrow After Thrombectomy.

36

42566077

Fluoride exposure induces oxidative damage in primary astrocytes of SD rats and changes in the expression of α-synuclein and its effect on Nrf2-NQO1/HO-1 signaling pathway.

37

42566018

Retraction Note: Chrysin attenuates traumatic brain injury‑induced recognition memory decline, and anxiety/depression‑like behaviors in rats: Insights into underlying mechanisms.

38

42565788

A peripheral perspective on brain health: vascular and skeletal muscle contributions.

39

42565506

Mapping basal ganglia circuitry in altered states of consciousness: from pathology to pharmacology.

40

42565404

[Informative value of instrumental methods in assessing the anatomical and functional state of the corticospinal tract in children with severe traumatic brain injury].

41

42565342

Mild neonatal hypoxic-ischemic encephalopathy: current evidence and ongoing controversies.

42

42565112

Late neurologic and functional outcomes in patients with severe anoxic brain injury after cardiopulmonary arrest: a multicenter cohort study.

43

42564964

Baseline Performance on Concussion Assessments of Athletes Who Are Deaf or Hard of Hearing.

44

42564771

Central neuroendocrine dysregulation in ischaemic stroke sequelae: pathophysiological mechanisms-a narrative review.

45

42564725

Structural brain injury on magnetic resonance imaging in heart failure and identifying patients at high-risk.

46

42564671

Characteristics of Athletic Trainers That Influence Personal Subjectivity in Medical Disqualification From Sport Following Concussion Discussions.

47

42564511

Correlation of Contusion Morphology and Volume With Functional Recovery and in Hospital Mortality in Traumatic Brain Injury.

48

42564451

Continuum of Irreversible and Potentially Reversible Traumatic Brain Injury Sequelae: Axonal Injury and Hydrocephalus.

49

42564439

Automated Semisupervised Measurement of Optic Nerve Sheath Diameter From CT Following Traumatic Brain Injury.

50

42564423

Outcomes of Surgical Versus Conservative Management in Severe Traumatic Brain Injury (GCS 3-4) With Evacuable Mass Lesions: A Retrospective Cohort Study.

51

42564368

Pediatric Repetitive Mild Traumatic Brain Injury Elicits T Cell-Mediated Neuroinflammation.

52

42564358

Predicting Traumatic Brain Injury Outcomes: The Intersection of Clinical Signs, Laboratory Indicators and Radiology.

53

42564300

Brain-Dead Organ Donation in Neurosurgical Care: Roles of Neurosurgeons and Collaboration With the Korea Organ Donation Agency (KODA).

54

42564143

Efficacy of early enteral nutrition in patients with traumatic brain injury: a systematic review and meta-analysis.

55

42564064

Traumatic brain injury in patients with mechanical heart valves on lifelong anticoagulation: incidence, management, and outcomes of intracranial hemorrhage.

56

42563932

Early-Life Clinical Factors Shape Cerebellar Structure in Preterm-Born Children.

57

42563917

Pediatric Neuropalliative Medicine Clinic: Five-Year Data Characterizing a Novel Model of Outpatient Care.

58

42563522

Region-Specific Brain Imaging Correlates of Repetitive Head Impact Exposure in Nonconcussed High School Football Players.

59

42563249

Injectable Supramolecular Hydrogel Encapsulating CRISPR-Engineered MSCs Drives Synergistic Neuroprotection and Functional Recovery After Traumatic Brain Injury.

60

42563206

Lifetime Concussions and Head Impact Exposure During Collegiate Athletics: A CARE Consortium Study.

61

42562855

Phenotype-specific white matter microstructural alterations and their clinical correlates in Wilson disease.

62

42562771

Vascular risk factors’ impact on motor performance and sensorimotor network structural integrity in multiple sclerosis.

63

42562704

Impact of the hybrid emergency room system on long-term functional outcomes in severe traumatic brain injury.

64

42562625

Everolimus for the treatment of neuropsychological deficits in tuberous sclerosis complex: findings from the TRON multicentre randomised controlled trial.

65

42562624

Fifteen-minute consultation:The mimics of cerebral palsy-looks like CP but isn’t.

66

42562440

Early hand preference and infantile spasms: A case of left-sided cerebral palsy.

67

42562380

Factors Associated With Accelerated Fracture Healing in Patients With Traumatic Brain Injury and Extremity Comminuted Fractures: A Retrospective Case-Control Study.

68

42562329

Creatine preserves mitochondrial integrity and ameliorates early epileptiform activity and cognitive impairment via regulation of Na⁺,K⁺-ATPase in adolescent rats with severe traumatic brain injury.

69

42562179

Assessment and Management of Spastic Shoulder in Patients with Brain Injury.

70

42562073

Mas receptor activation promotes mitophagy and preserves neuronal function after traumatic brain injury.

71

42562060

Effects of Brain-Computer Interface-Based Training on Post-Stroke Lower Limb Rehabilitation: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

72

42561872

A Nationwide Analysis of Hospital Disposition After Tracheal Intubation Among Elderly Patients Admitted From the Emergency Department.

73

42561605

An examination of the association between physical health conditions and lifetime suicide attempts.

74

42561535

Kinematic-muscular synergies describe coupled neuro-muscular control and biomechanics of locomotion in children with cerebral palsy.

75

42561489

Neuroimmune mechanisms of the gut-brain axis in treatment-resistant depression: Implications for microbiome-based therapeutic strategies.

76

42561382

Adaptive seating for children with cerebral palsy classified as Gross Motor Function Classification System (GMFCS) levels IV and V at General Justice Gizenga Mpanza Regional Hospital in KwaZulu-Natal, South Africa: a mixed methods study.

77

42561381

Commentary on reflections on participation in the community, as self-reported by young people with cerebral palsy.

78

42560998

Surgical stabilization of flail chest: Patient selection, hospital variation, and outcomes.

79

42560759

A trans-therapeutic signature of recovery in internet gaming disorder: From shared network reorganization to molecular underpinnings.

80

42560357

Effects of a Virtual Reality-Based Balance Training Program on Clinical Outcomes and Cortical Oscillatory Activity: A Combined Behavioral and EEG Study.

81

42560351

Motor learning in children with movement difficulties: A modified Delphi study of influencing factors.

82

42560280

Neuropsychiatric Consequences of Subjective Return-to-Activity Measures.

83

42560270

A Hybrid Paradigm to Develop Head Injury Criteria for Behind Helmet Blunt Trauma.

84

42560204

Provider Perceptions of Current Concussion Care Practices for Active Duty Service Members.

85

42560200

Exploring the Relationship Between Hearing Status, Cognitive Function, and Neurological Symptom Burden: The Impact of Hearing Aids on Veteran Health.

86

42560025

A scoping review of therapies to support marriages and partnerships after acquired brain injury.

87

42559698

Three-Year Outcomes Following Hip Reconstruction in Cerebral Palsy: A Population-Based Analysis.

88

42559649

mPFC hemorrhage induces hippocampal CA1 dendritic spine plasticity and attentional deficits in mice.

89

42559473

Successful endoscopic evacuation of traumatic intracerebral hemorrhage: A report of two cases.

90

42559466

Delayed traumatic spinal epidural hematoma after mild traumatic brain injury successfully treated with minimally invasive technique: A case report.

91

42559368

Economic burden and cost drivers of traumatic brain injury.

92

42559270

Head Impact Exposure Across Levels of Play in American Football: A Systematic Review of Accelerometer Data.

93

42559265

Transient Bilateral Fixed Dilated Pupils Following Papaverine Use During Intracranial Microvascular Decompression: A Case Report.

94

42559224

Genetic factors complicating recovery in patients with brain injury: Possible link between injury severity and posttraumatic neurodegeneration related to intracerebral amyloid deposition – A narrative review.

95

42559177

Decoding everyday levels of musical training from subcortical white-matter architecture.

96

42558972

The Response of the Default Mode Network to Aerobic Exercise in Pediatric Concussion.

97

42558887

Lacosamide Use After Traumatic Brain Injury: A Scoping Review.

98

42558789

A Multiliteracies Approach to Transforming Written Cases Into Video Case Studies in Rehabilitation Education: A Design-Based Study.

99

42558785

Comparison of Growth Modulation of Proximal Femur Physis in Cerebral Palsy and Developmental Dysplasia of Hip: A Systematic Review and Meta-analysis.

100

42558633

Efficacy and Safety of Hopantenic Acid in Pediatric Neurological and Developmental Disorders: A Systematic Review and Meta-Analysis.

101

42558534

Beyond motor dysfunction: comorbidities in children with cerebral palsy: a retrospective observational study from a tertiary paediatric hospital in the UAE.

102

42558527

Oxidative stress as a driver of organelle cascade damage in neurological diseases.

103

42558442

Exercise as an adjunct intervention for social anxiety disorder: a mini-review.

104

42558067

Colchicine for the Prevention of Vascular Events After an Acute Intracerebral Hemorrhage: A Placebo-Controlled Trial.

105

42558045

Gas-6 Scavenges Anionic Phospholipid-Expressing Microparticles and Mitigates TBI-Induced Endotheliopathy and Coagulopathy in Mice.

106

42557968

Multipathway modulation of neuroinflammation and oxidative stress by hesperidin in a rat single prolonged stress model of post-traumatic stress disorder.

107

42557830

Comparison of Synchronous Telerehabilitation and Face-to-Face Methods on Upper Extremity Function in Children with Hemiparetic Cerebral Palsy.

108

42557611

Sport-Related Concussion Prevention Programs in Soccer: A Scoping Review Using the RE-AIM Framework.

109

42557515

Trends and disparities in gun violence-related neurotrauma incidence, prevalence, and disability across the United States, 1990-2023: A population-based analysis of the Global Burden of Disease database.

110

42557490

Hematopoietic Growth Factors Induce More Extensive Transcriptomic Remodeling in Cerebral Monocytes/Macrophages than in Microglia During the Chronic Phase of Traumatic Brain Injury.

111

42557436

Albumin-Anchored Thromboinflammatory Ratios Provide Modest Incremental Prognostic Value Beyond Clinical Severity Scores in Aneurysmal Subarachnoid Hemorrhage: A Retrospective Study.

112

42557435

The Effects of Transport Altitude on Outcomes in Traumatic Brain Injury (HEIGHT-TBI): An Observational Cohort Study.

113

42557135

Clinical outcomes of transposition osteotomy of the acetabulum for neurogenic hip dysplasia in skeletally mature patients.

114

42556987

Drugs and Cell-Based Therapies for the Prevention and Treatment of Neonatal Brain Injury.

115

42556981

Proven Neonatal Neuroprotection Strategies: Magnesium Sulfate and Therapeutic Hypothermia.

116

42556773

C1q dependency of retinal ganglion cell death in blast-mediated traumatic brain injury.

117

42556720

Modified Expansion-Floating Craniotomy for Refractory Intracranial Hypertension:A Technical Review and Case Series.

118

42556656

The role of PANoptosis regulatory networks in acute neurological injury.

119

42556602

Altered Mechanical Somatosensory Processing in Young People with Cerebral Palsy: A Multisite Quantitative Sensory Testing Study.

120

42556487

Microglial SREBP2 regulate cholesterol-related lipid metabolism and inflammatory levels following ischemic stroke via the autophagy pathway.

121

42556280

Propranolol attenuates systemic inflammatory response in aged traumatic brain injury patients.

122

42556181

Effect of extracorporeal shock wave therapy (ESWT) on gastrocnemius muscle spasticity among cerebral palsy children: A randomised controlled trial with sonographic evidence.

123

42556048

Comparing PROMIS Global Health and Rivermead Post-concussion Symptoms Questionnaire in adult traumatic brain injury.

124

42556001

Association of time-averaged systemic immune-inflammation indices with in-hospital mortality after intracerebral hemorrhage: a retrospective study.

125

42555976

Esketamine alleviates neuroinflammation and cognitive impairment in male 3xTg-AD mice by regulating the TAOK1/IL-17 axis.

126

42555907

Distinct Patterns of Syntactic Errors Doubly Dissociate in Chronic Poststroke Aphasia.

127

42555850

Endothelin-1 Signaling Mediates Hypoxia-Induced Microglial Activation Through Reactive Oxygen Species and Mitogen-Activated Protein Kinase Pathways.

128

42555794

A 3-n-butylphthalide-based nanoagent modulates PINK1/Parkin-associated mitophagy signaling in ischemia-reperfusion brain injury.

129

42555369

Extensive Biventricular Subendocardial Infarction with Cardiogenic Shock as Secondary Brain Hit in an Asphyxiated Neonate-Case Report.

130

42555051

The relative importance of work-related factors on return to work in adults with persistent postconcussion symptoms – A cohort study.

131

42554671

Role of β-Arrestin2 Signaling in Neuropharmacological Effects of Psychedelic Drugs.

132

42554560

Social Isolation and Loneliness After Brain Injury: What Can Be Done? A Guide for Individuals With Brain Injury.

133

42554325

Case report: Adult presentation of glutaric aciduria type I.

134

42554164

Glymphatic-meningeal lymphatic dysfunction drives remote organ injury after aneurysmal subarachnoid hemorrhage: a unified neuroimmune framework and time-stratified therapeutic roadmap.

135

42554104

Characterizing the Prevalence of Dementia Risk Factors in Moderate-to-Severe Traumatic Brain Injury.

136

42554099

Letter: Recovery from Traumatic Brain Injury Takes Months; Our Care Systems Last Weeks.

137

42553827

Role of transcranial Doppler pulsatility index for predicting neurological deterioration in mild-to-moderate traumatic brain injury patients in intensive care unit.

138

42553698

Concussion is associated with multiple sclerosis if it occurs before infectious mononucleosis.

139

42553473

Predicting Outcomes of Traumatic Brain Injury Using Machine Learning Models Among Patients at Kilimanjaro Christian Medical Centre, Tanzania: A Registry-Based Cohort Study.

140

42553406

Peripheral and Central Administration of Soluble Glycoprotein 130 Improves Cognitive Outcomes Following Controlled Cortical Impact in Male Mice.

141

42553321

Effect of Parent-Mediated Home-Based Rehabilitation Program for Enhancing Functional Outcomes and Participation in Children With Diplegic Cerebral Palsy: A Case Series.

142

42553277

Meta-analysis of the effects of lower extremity exoskeleton robot on the improvement of walking ability and curative effect in SCI patients.

143

42553245

A brief checklist of modifiable dementia risk factors (RF12): associations with cognitive and affective measures in an Italian cohort.

144

42553203

Real-time approach to evaluate spinal cord topography of motor pool activation during gait.

145

42553201

Persistent hypersensitivity after repeat concussion is associated with chronic cognitive dysfunction.

146

42553153

Associations between arterial oxygenation and oxidative stress markers in serum and bronchoalveolar lavage fluid of patients with severe brain injury.

147

42552917

Short-chain fatty acid-producing psychobiotics in mood disorders: mechanistic insights into the microbiota-gut-brain axis.

148

42552585

Postural Control in Children with Diplegic Cerebral Palsy: The Association with Cervical Joint Position Sense Error.

149

42552491

Early vs. late computed tomography angiography in blunt cerebrovascular injuries: a national analysis of clinical outcomes across injury grade and location.

150

42552489

p-Coumaric Acid Attenuates Lead Acetate-induced Neurotoxicity in Rats by Improving Behavioral Dysfunction and Suppressing Oxidative Stress, Neuroinflammation, Apoptosis, and Plasticity-related Molecular Alterations.

151

42552236

Reducing Re-admission Risk After Traumatic Brain Injury: Focus on the Early Post-Discharge Interval.

152

42552015

Neuromonitoring: an overview.

153

42551788

Perioperative Mammillary Body Injury on MRI in Neonates with Severe Congenital Heart Disease.

154

42551754

Gaps in Intracranial Pressure Monitoring for Traumatic Brain Injury in China: A Clinician Survey.

155

42551499

Electrocardiographic abnormalities secondary to acute central nervous system injury.

156

42551445

Sex-Based Differences in Severe Trauma and Hemorrhagic Shock: A Systematic Review of Pre-Clinical and Veterinary Animal Studies.

157

42551197

STING inhibition alleviates post-cardiac arrest brain injury by suppressing microglia-mediated neuroinflammation via the cGAS/STING/NF-κB pathway.

158

42551100

Cost-effectiveness analysis of HABIT-ILE in preschool children with bilateral cerebral palsy: a multicenter randomized controlled trial.

159

42550802

Retraction: Tert-Butylhydroquinone Alleviates Early Brain Injury and Cognitive Dysfunction after Experimental Subarachnoid Hemorrhage: Role of Keap1/Nrf2/ARE Pathway.

160

42550704

Oxygen Saturation Thresholds for Opioid-induced Respiratory Depression: A Systematic Review.

161

42550737

Evaluating Point-of-Care Electroencephalogram for Mild Traumatic Brain Injury Triage and Referral Pathways Within the Emergency Department: A Mixed-Design Cohort Quality Improvement Study.

162

42550473

Developing a neuropsychiatry curriculum for clinical psychologists and neuropsychologists: An e-Delphi study.

163

42550472

Long-term prediction of epilepsy following traumatic brain injury among veterans using routine clinical data.

164

42550293

Caspase-1-mediated pyroptosis drives secondary thalamic neurodegeneration after focal cerebral infarction.

165

42549635

Hippocampal Subfield Volumetry and Navigation in Congenital Blindness.

166

42549197

Mixed-Nerve Silent Period Characteristics During Muscle Output Regulation in Healthy Athletes: Preliminary Findings and Comparison with a Single Postoperative Case.

167

42548882

Sustained abstinence in severe ketamine use disorder following ibogaine treatment case report.

168

42548880

Dapagliflozin and cognitive impairment: pharmacological mechanisms, translational evidence, and future directions.

169

42548303

Retrospective analysis of temporalis muscle thickness as a biomarker of functional level in adults with cerebral palsy.

170

42547960

Pelargonium Graveolens Essential Oil Improves Recovery after Experimental Traumatic Brain Injury.

171

42547841

Microglial maturation across human and mouse as a reference for interpreting large-animal models of perinatal brain injury.

172

42547675

Impact of Initial Care at a Neurosurgery-Capable Facility on Mortality Among Patients with Moderate-to-Severe Traumatic Brain Injury in South Africa.

173

42547674

Waveform-Derived Metrics of Intracranial Compliance: Validation and Pulsatile Dynamics.

174

42547673

Surgical Versus Medical Management in Older Adults with Traumatic Brain Injury: A Systematic Review and Meta-analysis.

175

42547454

Let us stop admiring the problem: we need social prescribing for children with disability now.

176

42547119

Capacity Building Through Psychedelic-Assisted Therapy: Navigating Social Determinants of Health.

177

42546807

CKLF1 upregulation exacerbates secondary brain injury after intracerebral hemorrhage by promoting neuronal ferroptosis and oxidative stress.

178

42546743

Early versus Late Pharmacologic Thromboprophylaxis in Traumatic Brain Injury: A Propensity-Score Matched Cohort Study.

179

42546603

Neuroimaging biomarkers of non-invasive brain stimulation in post-stroke recovery: EEG and fMRI perspectives.

180

42546483

Retrospective study of effectiveness of high versus low intensity robotic gait training in combination with physiotherapy for pediatric cerebral palsy patients.

181

42546448

Elevated plasma glucagon-like Peptide-1 levels are associated with enteral feeding intolerance in traumatic brain injury.

182

42546262

Palliative hip surgery in nonambulatory children with cerebral palsy: outcomes of two surgical techniques.

183

42545971

Senescence Associated With Neurodegeneration: Simultaneous Assessment of β-gal Activity And Nissl Stain In Histological Sections of Rodent Brain.

184

42545797

Diagnostic accuracy of blood biomarkers for excluding head CT abnormalities after mild traumatic brain injury in adults: a systematic review and meta-analysis.

185

42545489

MRI-based cortical morphometry in traumatic brain injury: a pilot longitudinal study.

186

42545486

[Diagnostic algorithm for the management of patients ≥ 65 years with a mild traumatic brain injury in the emergency department].

187

42545357

Multidomain mobility and cognition across the adult lifespan: Stride velocity and cadence are associated with executive function in older adulthood.

188

42545137

Lithium carbonate attenuates behavioral alterations and partially reverses reduced prefrontal BDNF mRNA expression induced by post-weaning social isolation in male rats.

189

42544925

Special Issue: Does latent Toxoplasma infection mimic the immune profile of schizophrenia? Sex-specific cytokine and brain-marker alterations suggest partial overlap.

190

42544625

Beyond mood: the neurobiological rationale for using SSRIs and SNRIs in the care of inflammatory bowel disease and disorders of gut-brain interaction.

191

42544550

Where is the sweet spot for psychedelic-enhanced fear extinction? An integrative quantitative synthesis of dose-effect patterns in rodent models.

192

42544146

Effect of Combined Pulley and Vibration Therapy on Spasticity and Motor Function in Children with Cerebral Palsy and Genu Recurvatum: A Quasi-Experimental Study.

193

42543730

Correction to ‘Multidisciplinary Perioperative Care of a One-Month-Old Infant With Severe Traumatic Brain Injury and Brain Herniation: A Case Report’.

194

42543483

Association of protocol-driven care with complication rates in severe traumatic brain injury: a two-hospital quasi-experimental study in a resource-limited setting.

195

42543112

Pressure-dependent effects of hyperbaric oxygen on hippocampal CREB-BDNF signaling and associated changes in synaptic plasticity and recognition memory in healthy rats.

196

42543004

Sleep MAPP: a decision support tool for guideline-concordant sleep care in the polytrauma/traumatic brain injury system of care.

197

42542820

Noninvasive Urinary Biomarkers for Early Diagnosis of Mild Traumatic Brain Injury.

198

42542724

Cerebral palsy in a Sudanese tertiary setting: toward a more robust methodological framework.

199

42542686

The assessment of risk factors for cerebral palsy should also include genetic testing, especially if parents are consanguineous.

200

42501448

Offline and online de novo motor skill learning differs in young children and adults.

Creator Credentials

Author: Matt Palaszynski

  • Founder, BRIGHT Foundation: Leading a global initiative to “close the loop” on Cerebral Palsy recovery through data-driven research.
  • 25+ Years Lived Experience: Navigating life with a daughter with CP provides a primary, first-person understanding of the physiological and clinical gaps in current care models.
  • GE Alumnus & Business Leader: Leveraging decades of experience in operational excellence, complex systems, and strategic leadership to apply rigorous meta-study frameworks to neurological research.
  • Methodology: Combines personal advocacy with professional systems-thinking to synthesize NCBI PubMed data into the actionable NeuroLoop Protocol.

Conflict of Interest Statement

The BRIGHT Foundation and its founder, Matt Palaszynski, maintain no commercial or business interests in the medical technologies, pharmaceutical products, or clinical services discussed on this page.

  • Non-Profit Mission: Our objective is purely research-driven, aimed at identifying the most effective paths to a functional cure.
  • Independence: No funding is received from manufacturers of the devices or therapies reviewed in our weekly meta-studies.
  • Transparency: All citations are linked directly to PubMed (PMIDs) to ensure users can verify the raw data independently.